diacylglycerol/neoplasms

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Inhibition of diacylglycerol kinase to augment adoptive T cell transfer

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BACKGROUND OF THE INVENTION Elicitation of T-cell effector responses requires signal transduction through the T-cell antigen receptor (TCR), a protein complex that binds antigenic peptide presented by MHC, as well as through costimulatory receptors such as CD28. The effector responses generated from

Tumor treatment method

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FIELD OF THE INVENTION The present invention relates to a method of treating a solid tumor, and in particular, to a method involving hypoxic stress as one component and protein kinase C activation as another component. REFERENCES Cook, P. F., et al., Biochem. 21: 5794-5799 (1982). Culver, K., et

Radioiodinated diacylglycerol analogues and methods of use

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BACKGROUND OF THE INVENTION This invention relates to iodinated and radioiodinated compounds which are useful as biological reagents and tracers, and more specifically, to iodinated and radioiodinated diacylglycerol analogues. Diacylglycerols have recently been attracting attention because of their

Substituted naphthyridinone compounds useful as T cell activators

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DESCRIPTION The present invention generally relates to substituted naphthyridinone compounds that activate T cells, promote T cell proliferation, and/or exhibit antitumor activity. Provided herein are substituted naphthyridinone compounds, compositions comprising such compounds, and methods of their

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