Dichloromethane (DCM) is a lung and liver carcinogen in mice at inhalation exposures≥2000ppm. The modes of action (MOA) of these responses have been attributed to formation of genotoxic, reactive metabolite(s). Here, we examined gene expression in lung and liver from female B6C3F1 mice exposed to 0,
A high performance liquid chromatography (HPLC) method was developed and validated for the determination of 7-chloro-3-[[(N,N-dimethylamino)propyl]amino]-2-quinaxolinecarbonitri le 1,4-di-N-oxide (Q-85), a new hypoxia-selective agent, in plasma. The assay involves extraction into
Dichloromethane (DCM) is a clear, waterwhite, non-inflammable liquid of high volatility and sweet aromatic odor. It is widely used as an industrial solvent. In considering its neurotoxicity the CNS-depressant effects of both narcotic and hypoxic action must be taken into account, hypoxia being
Acute poisoning with organic solvents and other volatile compounds now usually follows deliberate inhalation (volatile substance abuse) or ingestion of these compounds. Solvents from adhesives, typewriter correction and dry cleaning fluids, cigarette lighter refills (butane) and aerosol propellants
Continuous irradiation during photodynamic therapy (PDT) process inevitably induces tumor hypoxia, thereby weakening the PDT effect. In the PDT induced temporary hypoxia, sustainably providing singlet oxygen from stored chemical energy may enhance the cell killing effect and boost the
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