digitoxin/infarction

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Digitoxin-associated mortality in acute myocardial infarction.

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The use of digitalis in patients who have sustained an acute myocardial infarction has been controversial. A number of reports have suggested that the use of the glucoside actually can increase mortality. In all previous reports, digoxin has been the glucoside in use. In 620 patients admitted to

Digitoxin prolongs survival of female rats with heart failure due to large myocardial infarction.

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BACKGROUND We analyzed whether digitoxin affects the survival of rats with congestive heart failure. RESULTS The influence of digitoxin (0.1 mg.100 g.day, orally) on the survival of infarcted female rats (n=170) randomized as Control Infarcted (CI, n=85) or Digitoxin (D, n=85) was evaluated for 280

[Therapeutic experiences with digitoxin in sinus and ventricular tachycardia caused by infarct].

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[Digitoxin therapy of an ventricular flutter attack complicating an infarction of the posterior wall].

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Severity of the cardiac impairment determines whether digitalis prolongs or reduces survival of rats with heart failure due to myocardial infarction.

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BACKGROUND The aim of the present study was to evaluate if the influence of digitalis on survival depends on the severity of cardiac dysfunction in heart failure (HF). RESULTS Doppler echocardiogram (DE) parameters were analyzed in 84 Wistar control (C) and 80 Wistar rats treated with 0.1mg/100g/day

Concentration of digoxin, methyldigoxin, digitoxin and ouabain in the myocardium of the dog following coronary occulsion.

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26 mongrel dogs were given a single dose of 0.03mg/kg tritium-labelled digoxin, beta-methyldigoxin, digitoxin or ouabain 2 hrs or 95 hrs following experimental coronary occlusion. Examination of the epicardial ECG was performed by moving from intact to ischemic or necrotic zones. 60 min after

Digitoxin Attenuates Heart Failure, Reduces Myocardial Hypertrophy, and Preserves the Calcium-Binding Proteins in Infarcted Rats.

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We previously showed that digitoxin prolongs the survival of rats with heart failure due to myocardial infarction (MI). In this study, we evaluated the effect of digitoxin on myocardial structure, ventricular function, and proteins involved in calcium kinetics. Seventy-two rats with MI >35% of

[Drug therapy under physical conditioning and during phase III rehabilitation in patients following acute myocardial infarct].

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In the framework of the secondary prevention after acute myocardial infarction the interaction between physical conditioning (pK) and medicamentous therapy was analysed and a retrospective evaluation of the therapy was performed during the rehabilitation phase III. During the physical conditioning

[Digoxin: the results of the DIG study in the XXI century].

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After the report that there was no statistical significance in the general mortality of the DIG study, the indication of digoxin in the treatment regimens for congestive heart failure (CHF) drastically decreased. Post hoc studies that reassessed the DIG study data, indicated that an aspect that was

Survival and prognosis: investigation of Crataegus extract WS 1442 in congestive heart failure (SPICE)--rationale, study design and study protocol.

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SPICE is the first, international, randomized, placebo-controlled, double-blind study to investigate the influence of the herbal drug Crataegus Special Extract WS 1442 (hawthorn leaves with flowers) on mortality of patients suffering from congestive heart failure. BACKGROUND In vitro and

[Problems of therapy in very old age (author's transl)].

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The care of the elderly covers a wide spectrum: 1, The prophylaxis of the relatively healthy olds. 2, The somatic, psychic and social care of the handicapped aged. 3, The treatment of special illnesses in old age. The gerotherapy must consider the characteristics of the biological age and the degree

Factors of importance for valid digitalis assays particularly for the determination of digoxin in plasma and urine.

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Four commercial radioimmunoassay (RIA) kits for digoxin varied in precision (coefficient of variation, CV within-assays 5-14%) and accuracy (up to 40%). Thus it seems that such commercial RIA-kits can reach at best a CV within-assay of 5% and a similar variation between assays. Without a good

Problems of an optimum digitalis therapy.

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In 25 digitalized patients with ischaemic heart disease who had survived a myocardial infarction for 2 to 4 weeks, the systolic time intervals (STI) and changes of glycoside plasma level were measured before and up to 5 hrs after oral intake of a maintenance dose of digitoxin (n = 18) or of digoxin

The cardiac glycoside-receptor system in the human heart.

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Specific binding sites have been demonstrated to exist in the heart for several drugs and hormones such as beta-blocking agents, cardiac glycosides, catecholamines, insulin, glucagon and acetylcholine. The specific binding sites for cardiac glycosides in the human heart have certain properties which

[Sex, erectile dysfunction, and the heart: a growing problem].

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BACKGROUND Erectile dysfunction (ED) is defined as the inability to attain and/or maintain penile erection sufficient for satisfactory sexual performance. ED may also be an early sign of cardiovascular disease. The main risk factors for coronary heart disease (high LDL, smoking, hypertension,

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