Disclosed is a pharmaceutical composition for the prophylaxis and therapy of inflammatory diseases, allergic diseases, or asthma, comprising a velvet apple (Diospyros blancoi A. DC.) extract as an active ingredient. Having the inhibitory activity against the nuclear translocation of NF-.kappa.B, whose level is rapidly elevated in response to inflammatory stimuli, the velvet apple extract can suppress the production of NO and PGE.sub.2, the expression of iNOS and COX-2, and the release of IL-1.beta. and TNF-.alpha., and can significantly down regulate Th2-mediated IL-4 and IL-13 production. In addition, the extract was found to inhibit the activation of eosinophils in bronchoalveolar lavage fluid, and to suppress the secretion of immunoglobulins and chemokines in bronchoalveolar lavage fluid and blood, as measured by in vivo tests on an ovalbumin-induced asthma mouse model. Therefore, the extract can be used in the method for preventing or treating various inflammatory disorders, allergic diseases, or asthma.

Ahn; Kyung Seop

Kwon; Ok-Kyoung

Oh; Sei Ryang

Kim; Jung Hee

Lee; Hyeong Kyu

Lee; Mee-Young

Son; Hwa-Young

Lee; Kyoung-Youl

Kim; Soo Yong

Tomayo-Castillo; Giselle

Rosales-Ovares; Katia

Gamez-Lobo; Rodrigo

Korea Research Institute of Bioscience and Biotechnology

Pharmaceutical composition for preventing or treating inflammatory diseases, allergic diseases or asthma, containing Diospyros blancoi A. DC. extract as active ingredient

Disclosed is a method for preventing, improving and/or treating cornea damage or a corneal disease, including administering an effective amount of an extract of a persimmon tree for preventing, improving or treating cornea damage to a subject in need thereof. The extract may be a persimmon leaf extract and the extract is effective in suppressing inflammation of the cornea and protecting corneal cells.

Korea Institute of Science and Technology

Method for preventing, improving or treating cornea damages using extracts of Diospyros kaki

diospyros carbonaria

inflammation

diospyros

diospyros carbonaria/inflammation

Pharmaceutical composition for preventing or treating inflammatory diseases, allergic diseases or asthma, containing Diospyros blancoi A. DC. extract as active ingredient

Method for preventing, improving or treating cornea damages using extracts of Diospyros kaki

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