One new lycopodine-type Lycopodium alkaloid, dehydroisofawcettiine N-oxide (1) and eleven known analogues (2-12) were isolated from the whole plant of Diphasiastrum complanatum. The new structure was established on the basis of spectroscopic methods, including 2D NMR techniques. The absolute
The genus Diphasiastrum includes at least 23 species distributed primarily across the northern temperate and subarctic areas of the world. These plants produce an array of lycopodium alkaloids, and some species such as Diphasiastrum complanatum have been used in traditional medicine for ages for
Free radical-induced oxidative damage is implicated in the pathogenesis of neurodegenerative disorders, and antioxidants are presumably of therapeutic value in such diseases. Our previous data indicated that free radicals are strongly associated with brain aging and also play an important role in
Imbalance between production and scavenging of free radicals and other reactive oxygen species (ROS) is a component of many diseases, but it is especially important in aging-related diseases of the central nervous system. Oxidative stress-induced neuronal dysfunction plays an important role in the
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