A male landscaper presented with an acute confusional state following intentional ingestion of Duboisia myoporoides. With supportive care, he made an uneventful recovery after 24 h. Clinical features, investigation and management of Duboisia poisoning are discussed.
Tropane alkaloids (TAs), especially hyoscyamine and scopolamine, are important precursors for anticholinergic and antispasmodic drugs. Hyoscyamine and scopolamine are currently obtained at commercial scale from hybrid crosses of Duboisia myoporoides × Duboisia leichhardtii plants. In this study, we
Australian native trees of the genus Duboisia contain high concentrations of atropine-like alkaloids, especially hyoscine. Occupational exposure to the dried plant material results in two clinical syndromes: "cork-eye", and being "corked up". Plant abuse, as an intoxicant and hallucinogen, also
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