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Page 1 from 35 results
Method of assaying leukocyte elastase inhibitor for the in vitro diagnosis of colorectal cancer
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The present invention relates to the cancerology field. More particularly, the subject of the present invention is a method for the in vitro diagnosis of colorectal cancer in a human patient, by determining the presence of the Leukocyte Elastase Inhibitor (LEI) in a biological sample taken from this
Method for regulating inflammation and tumor growth with calmodulin, calmodulin analogues or calmodulin antagonists
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TECHNICAL FIELD OF THE INVENTION
This invention relates to the field of substances which have anti-inflammatory or anti-tumor activity and to diagnostic testing of patients for regulation of tumor necrosis factor and elastase activity.
BACKGROUND OF THE INVENTION
Tumor necrosis factor (TNF) is an
Beta-hairpin peptidomimetics as selective elastase inhibitors
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The present invention provides .beta.-hairpin peptidomimetics which are useful as inhibitors of protease enzymes and are embraced by the general disclosure of, but not specifically disclosed in WO2006/087001 A1.
The .beta.-hairpin peptidomimetics of the invention are compounds of general formula
Beta-hairpin peptidomimetics as selective elastase inhibitors
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The .beta.-hairpin peptidomimetics of the invention are compounds of general formula cyclo(Xaa.sup.1-Xaa.sup.2-Thr.sup.3-Xaa.sup.4-Ser.sup.5-Xaa.sup.6-Xaa.sup- .7-Xaa.sup.8-Xaa.sup.9-Xaa.sup.10-Xaa.sup.11-Xaa.sup.12-Xaa.sup.13-), and pharmaceutically acceptable salts thereof, with Xaa.sup.1,
Enzyme-activated anti-tumor prodrug compounds
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FIELD OF INVENTION
The invention relates to prodrug compounds capable of targeting and delivering cytotoxic drugs to tumors and metastatic cells. The drugs are useful in the treatment of cancer.
BACKGROUND OF THE INVENTION
Although many drugs are known that kill cancer cells, there are apparently
Serine protease inhibitors-N-substituted derivatives
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The present invention relates to certain substituted oxadiazole, thiadiazole and triazole peptoids which are useful as inhibitors of serine proteases.
BACKGROUND OF THE INVENTION
The serine proteases are a class of enzymes which includes elastase, chymotrypsin, cathepsin G, trypsin and thrombin.
Method for increasing granulocyte number in a patient by administering superactive IL-33 fragments
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INTRODUCTION
Cytokines of the interleukin 1 family (IL-1) play a major role in a large number of autoimmune, infectious and inflammatory diseases (Sims J E and Smith D E, Nature Rev Immunology 2010). Interleukin 33 (IL-33), initially named NF-HEV, is a new cytokine of the IL-1 family comprising 270
Enzyme and DNA sequence encoding krill-derived multifunctional protein
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The present invention relates to purified nucleic acids encoding a krill-derived enzymes such as proteinases, which can be a multifunctional protein, and to purified polypeptides. A protein having "multifunctional activity," is defined herein as including at least one of a chymotrypsin, trypsin,
Multifunctional protein and DNA sequence encoding same
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The present invention relates to purified nucleic acids encoding a krill-derived multifunctional protein and to purified polypeptides having multifunctional activity. A protein having "multifunctional activity," is defined herein as including at least one of a chymotrypsin, trypsin, collagenase,
Antimicrobial uses of multifunctional enzyme
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The present invention relates to a krill-derived multifunctional enzyme and a family of crustacean and fish derived enzymes having substantial structural similarity to the multifunctional enzyme derived from antarctic krill. The invention additionally relates to the multifunctional enzyme, to
Crustacean and fish derived multifunctional enzyme
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The present invention relates to the discovery that there exists a family of crustacean and fish derived enzymes having substantial structural similarity to an enzyme derived from antarctic krill. The krill enzyme is the subject of U.S. patent application Ser. No. 08/338,501, filed Nov. 22, 1994,
Method for the prevention and treatment of scars with enzymes
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BACKGROUND OF THE INVENTION
Collagen is the major structural constituent of mammalian organisms and makes up a large portion of the total protein content of skin and other parts of the animal body. In humans, it is particularly important in the wound healing process and in the process of natural
Serine protease inhibitors-keto and di-keto containing ring systems
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The present invention relates to certain substituted oxadiazole, thiadiazole and triazole peptoids which are useful as inhibitors of serine proteases.
BACKGROUND OF THE INVENTION
The serine proteases are a class of enzymes which include elastase, chymotrypsin, cathepsin G, trypsin and thrombin.
Val-pro containing .alpha.-keto oxadiazoles as serine protease inhibitors
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BACKGROUND OF THE INVENTION
The serine proteases are a class of enzymes, which includes elastase, chymotrypsin, cathepsin G, trypsin and thrombin. These proteases have in common a catalytic triad consisting of Serine-195, Histidine-57 and Aspartic acid-102 (chymotrypsin numbering system). Human
Indole and tetrahydroisoquinoline containing Alpha-keto oxadiazoles as serine protease inhibitors
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The present invention relates to certain substituted oxadiazole nonpeptides, which are useful as inhibitors of serine proteases.
BACKGROUND OF THE INVENTION
The serine proteases are a class of enzymes, which includes elastase, chymotrypsin, cathepsin G, trypsin and thrombin. These proteases have in
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