estradiol 17 beta/obesity

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Estradiol-17 beta effects on lipid metabolism of adipose tissue in nutritionally induced lean and obese ovariectomized ewes.

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Nutritionally manipulated lean (68 kg) and obese (87 kg) ovariectomized ewes were administered estradiol-17 beta (E2) or sham implants. Ewes individually had ad libitum access to corn silage. Rates of de novo lipogenesis, palmitate esterification, and glycerol and fatty acid release were determined

Effects of obesity and ovarian steroids on insulin secretion and removal in sheep.

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The interactive effects of sex steroids and obesity on glucose metabolism and pancreatic secretion and organ removal of insulin were determined in multicatheterized lean and obese sheep by multiplying venoarterial concentration differences by plasma flows. Ovariectomized lean and dietary obese ewes

Effects of obesity on sex steroid metabolism.

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In a study designed to compare plasma androgens in obese, anovulatory women with non-obese, ovulatory women, we found a statistically significant increase in plasma androstenedione and testosterone in obese, anovulatory women. Plasma androstenedione was 252 +/- 18 ng/dl (mean +/- SEM) in the obese

Genomic modulation of diabetes (db/db) and obese (ob/ob) mutation-induced hypercytolipidemia: cytochemical basis of female reproductive tract involution.

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Infertility and hypercytolipidemic utero-ovarian involution are recognized consequences of the diabetes-obesity syndrome (DOS) in C57BL mice with either obese (ob/ob) or diabetes (db/db) single gene mutations. We have evaluated the interdependent deleterious influences of both mutation types and

Effects of obesity on insulin and glucose metabolism in cyclic heifers.

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Effects of degree of obesity on basal concentrations of insulin, glucose, thyroxine (T4), triiodothyronine (T3), estradiol-17 beta (E) and progesterone (P) were measured in serum from 50 estrous and 73 diestrous Holstein heifers and the insulin response to glucose infusion was assessed in diestrous

Direct intraovarian effects of leptin: impairment of the synergistic action of insulin-like growth factor-I on follicle-stimulating hormone-dependent estradiol-17 beta production by rat ovarian granulosa cells.

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The Ob gene product, leptin, is secreted by adipocytes and is required for fertility in the mouse. Leptin-deficient mice are obese and infertile, symptoms reminiscent of polycystic ovary syndrome (PCOS). Prior studies have shown that serum leptin levels are elevated in a significant sub-population

Arginine vasopressin secretion in non-obese women with polycystic ovary syndrome.

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Arginine vasopressin responses to osmotic (0.1 ml.kg-1.min-1 NaCl), orthostatic (standing upright and maintenance of orthostatic position for 20 min), and hypoglycemic (0.15 IU/kg insulin) stimuli were evaluated in women with polycystic ovaries and in normal subjects. Blood dehydroepiandrosterone,

Repolarization measures and their relation to sex hormones in postmenopausal women with cardiovascular disease receiving hormone replacement therapy.

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Women are more susceptible to the development of Torsades de Pointes ventricular tachycardia and have a longer heart rate-corrected QT interval than men. A causal role for estrogen has been implicated. The purpose of this study was to investigate if hormone replacement therapy (HRT) resulted in any

Cannabinoid type 1 receptor antagonists modulate transport activity of multidrug resistance-associated proteins MRP1, MRP2, MRP3, and MRP4.

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Cannabinoid type 1 (CB1) receptor antagonists have been developed for the treatment of obesity, but a major disadvantage is that they cause unwanted psychiatric effects. Selective targeting of peripheral CB1 receptors might be an option to circumvent these side effects. Multidrug

Neuroendocrine signals in the regulation of gonadotropin-releasing hormone secretion.

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Gonadotropin-releasing hormone (GnRH) is a key hypothalamic peptide that controls the secretion of pituitary gonadotropins, particularly luteinizing hormone (LH), and hence gonadal function. Hypothalamic GnRH is released in a pulsatile manner. In the female, the pattern of GnRH pulses, i.e., pulse

Hormonal and clinic evaluation of patients with moderate body hair growth.

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Plasma prolactin (PRL), gonadotropins (FSH, LH), estradiol-17 beta (E2), progesterone (P), total testosterone (T), sex steroid binding protein (SBP), T/SBP index, cortisol (F), 17-OH-progesterone (17OH-P), dehydroepiandrosterone sulphate (DHEA-S) and androstenedione (A), were measured in 50 fertile

Ovarian follicular recruitment, granulosa cell steroidogenic potential and growth hormone/insulin-like growth factor-I relationships in suckled beef cows consuming high lipid diets: effects of graded differences in body condition maintained during the puerperium.

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The effects of graded differences in body condition score (BCS) on ovarian follicular development, granulosa cell steroidogenic potential, and growth hormone (GH)-insulin-like growth factor-I (IGF-I) relationships were examined during the puerperium in beef cows fed high fat diets. Cows (n = 36)

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