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Page 1 from 95 results
Aromatic fluorine-containing organotin compounds and anti-tumour composition
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This invention relates to novel aromatic fluorine-containing organotin compounds and to anti-tumour compositions containing said compounds.
DISCLOSURE OF THE PRIOR ART
The substitution of hydrogen for fluorine substantially influences the biological activity of organic molecules (J. T. Welch,
Fluorine- and/or deuterium-containing compounds for treating non-small cell lung cancer and related diseases
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TECHNICAL FIELD
The invention generally relates to novel chemical compounds generated by structural modifications to an existing drug, osimertinib, via fluorination and/or deuteration, and pharmaceutical compositions and methods of preparation and use thereof. These compounds are biologically potent
Tumor imaging compounds
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The development of radiolabeled amino acids for use as metabolic tracers to image tumors using positron emission tomography (PET) and single photon emission computed tomography (SPECT) has been underway for two decades. Although radiolabeled amino acids have been applied to a variety of tumor types,
Tumor imaging compounds
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The development of radiolabeled amino acids for use as metabolic tracers to image tumors using positron emission tomography (PET) and single photon emission computed tomography (SPECT) has been underway for two decades. Although radiolabeled amino acids have been applied to a variety of tumor types,
Compositions and methods for imaging cancer
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FIELD OF THE INVENTION
The present invention relates to the field of radioimaging and, in particular, to radiolabelled compounds, methods of preparing the compounds and their use in imaging cancer.
BACKGROUND OF THE INVENTION
The somatostatin receptor subtype 2 (sstr2) is overexpressed in many
Triazine derivatives, compositions containing such derivatives, and methods of treatment of cancer and autoimmune diseases using such derivatives
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FIELD OF INVENTION
The present invention relates to compounds of the following formula:
##STR00002## wherein X is fluorine or chlorine; Y is oxygen, sulfur, or an imino group; R is an amino, hydroxyl, sulfonamide, or carboxamide group or an N-monomethyl or N-dimethyl analog thereof; m is an integer
Modulators of the p70S6 kinase for use in the treatment of brain disorders and triple-negative breast cancer
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CROSS REFERENCE TO RELATED APPLICATIONS
This application is a national stage filing under section 371 of International Application No. PCT/EP2016/053172, filed on Feb. 15, 2016, and published on Aug. 25, 2016 as WO 2016/131776, which claims priority to Great Britain Application No. 1502567.9, filed
Fluorine-substituted biphenyl butyric acids and their derivatives as inhibitors of matrix metalloproteinases
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BACKGROUND OF THE INVENTION
The present invention relates to novel fluorine-substituted biphenyl butyric acid compounds and their derivatives useful as pharmaceutical agents, to methods for their production, to pharmaceutical compositions which include these compounds and a pharmaceutically
Amino acid analogs for tumor imaging
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FIELD OF THE INVENTION
The invention includes novel chemical compounds having specific binding in a biological system and capable of being used for positron emission tomography (PET) and single photon emission (SPECT) imaging methods.
BACKGROUND OF THE INVENTION
The ability of analog compounds to
Amino acid analogs for tumor imaging
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FIELD OF THE INVENTION
The invention includes novel chemical compounds having specific binding in a biological system and capable of being used for positron emission tomography (PET) and single photon emission (SPECT) imaging methods.
BACKGROUND OF THE INVENTION
The ability of analog compounds to
Stilbene analogs and methods of treating cancer
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SEQUENCE LISTING
The instant application contains a Sequence Listing which has been submitted in ASCII format via EFS-Web and is hereby incorporated by reference in its entirety. Said ASCII copy, created on Mar. 20, 2012, is named SEQUENCE LISTING.txt and is 5.20 kilo bytes in size.
TECHNICAL
Fluorine-containing bisphosphonic acid derivative and use thereof
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CROSS-REFERENCE TO RELATED APPLICATIONS
This patent application is the U.S. national phase of International Patent Application No. PCT/JP2016/052960, filed on Feb. 1, 2016, which claims the benefit of Japanese Patent Application No. 2015-018260, filed Feb. 2, 2015, the disclosures of which are
Functionalized fluorine containing phthalocyanine molecules
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SEQUENCE LISTING
The instant application contains a Sequence Listing which has been submitted electronically in ASCII format and is hereby incorporated by reference in its entirety. Said ASCII copy, created on Nov. 18, 2014, is named SETON3.0E-006(E)_SL.txt and is 8,066 bytes in size.
FIELD OF THE
Fluorine-containing vitamin D3 analogues
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This invention relates to novel fluorine-containing vitamin D.sub.3 analogues which have excellent pharmacological activities, such as tumor cell differentiation-inducing activity and are expected to be used as a medicament.
PRIOR ART
It is known that a bio-metabolite of vitamin D.sub.3,
Treatment of symptoms of neoplastic diseases
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The present invention is concerned with a method of treating the symptoms of neoplastic diseases and more particularly, the use of fluorine containing acids for alleviating symptoms of neoplastic diseases without treating the disease itself.
The fluorine containing acid that can be administered to
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