Pregnancy

community health workers offering individual prenatal education to pregnant women

community health workers

Masindi

Intervention Trial to Measure the Effect of Individual Prenatal Information Combined With Mobile Phones

A Community Trial to Measure the Effect of Individual Prenatal Education With Mobile Phone Consultations Offered to Pregnant Women in Masindi and Kiryandongo, Western Uganda

We will measure the primary outcome of interest based on the number of days women delay to bathe their babies after delivery

Measure proportion of women who deliver their baby in a health centre

We will create a composite variable that will assess the level of birth preparedness based on primary variables mentioned in the protocol

Makerere University

Institute of Tropical Medicine, Belgium

Patients receiving a lysine restricted diet adjunct to pyridoxine therapy will be considered as participants in the 'exposure'/test group

Patients on pyridoxine mono-therapy will be participants in the 'control' group

Pyridoxine Dependant Epilepsy

Daily lysine intake will be managed to maintain a plasma lysine level of 50-80 µmol/L (normal range: 52-196 µmol/L). Diet prescriptions will be based on international guidelines for glutaricaciduria type I, another inborn error of lysine catabolism. In order to meet the recommended daily protein intake (DRI) [23,24], the diet may include commercially available lysine-free amino acid formulas approved for use in conditions affecting lysine metabolism, as well as commercially available low-protein products based on the participant's taste.

Lysine Restricted Diet

All participants will be on 15-30 mg/kg/day of pyridoxine therapy up to a maximum of 500mg/day divided in 2-3 doses enterally

Pyridoxine

Children's Hospital Colorado

Seattle Children's Hospital

BC Children's Hospital

Hannover Medical School

Maxima Medical Center

Kinderspital Zürich

University College London

Neurodevelopmental Outcome of Early Dietary Lysine Restriction in Pyridoxine Dependent Epilepsy Patients

Neurodevelopmental Outcome of Early Dietary Lysine Restriction in Pyridoxine

defined by total developmental index measured using the Bayley Scales for Infant and Toddler Development, 3rd Edition (Bayley-III)

folic acid/seizures

Intervention Trial to Measure the Effect of Individual Prenatal Information Combined With Mobile Phones

Neurodevelopmental Outcome of Early Dietary Lysine Restriction in Pyridoxine Dependent Epilepsy Patients

Folic Acid Supplementation in Phenytoin Induced Gingival Overgrowth

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