The native Brazilian plant Maytenus ilicifolia accumulates a set of quinone methide triterpenoids with important pharmacological properties, among which maytenin, pristimerin and celastrol that accumulate exclusively in the root bark of this medicinal plant. The first committed step in the quinone
Celastrol is a promising anti-obesity agent that acts as a sensitizer of the protein hormone leptin. Despite its potent activity, a sustainable source of celastrol and celastrol derivatives for further pharmacological studies is lacking.To elucidate the
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