Dementia refers to a set of symptoms and signs associated with a progressive deterioration of cognitive functions that affects daily activities.1 Symptoms may include memory loss and difficulties with thinking, problem-solving or language, as well as changes in mood, perception,
Cannabinoids are neuroprotective in models of neurodegenerative dementias. Their effects are mostly mediated through CB1 and CB2 receptor-dependent modulation of excitotoxicity, inflammation, oxidative stress, and other processes. We tested the effects of Sativex®, a mixture of
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