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A Dihydroxy-pentamethoxyflavone from Gardenia obtusifolia suppresses proliferation and promotes apoptosis of tumor cells through modulation of multiple cell signaling pathways.

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We sought to determine the molecular basis for the anticancer activities of 5,3'-dihydroxy-3,6,7,8,4'-pentamethoxyflavone (DH-PMF), isolated from Gardenia obtusifolia traditionally used in Thailand for a variety of ailments. As little as 1 μM DH-PMF inhibited the proliferation of prostate, colon,

A novel pentamethoxyflavone down-regulates tumor cell survival and proliferative and angiogenic gene products through inhibition of IκB kinase activation and sensitizes tumor cells to apoptosis by cytokines and chemotherapeutic agents.

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Most anticancer drugs have their origin in traditional medicinal plants. We describe here a flavone, 5,3'-dihydroxy-3,6,7,8,4'-pentamethoxyflavone (PMF), from the leaves of the Thai plant Gardenia obtusifolia, that has anti-inflammatory and anticancer potential. Because the nuclear factor-κB (NF-κB)

Gardenifolins A-H, Scalemic Neolignans from Gardenia ternifolia: Chiral Resolution, Configurational Assignment, and Cytotoxic Activities against the HeLa Cancer Cell Line.

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From the tropical plant Gardenia ternifolia Schumach. and Thonn. (Rubiaceae), eight stereoisomeric 2,3-dihydrobenzo[b]furan neolignans, named gardenifolins A-H (1a-d and 2a-d), were isolated and fully structurally characterized. Reversed-phase chromatography of a stem bark extract afforded two

Medicinal plants used in treatment and management of cancer in Kakamega County, Kenya.

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BACKGROUND Traditional medicine plays a critical role in treatment of chronic debilitating and life threatening conditions and diseases. Cancer is one such condition whose therapeutic intervention is commonly through inexpensive traditional herbal remedies. Increasingly industrialised societies are

Gardenia jasminoides inhibits tumor necrosis factor-alpha-induced vascular inflammation in endothelial cells.

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Inflammatory mediators such as tumor necrosis factor-alpha (TNF-alpha) enhance binding of low-density lipoprotein to endothelium and upregulate the expression of endothelial leukocyte adhesion molecules during atherogenesis. The present study examined the effect of ethanol extract of Gardenia

Dichloromethane fraction from Gardenia jasminoides: DNA topoisomerase 1 inhibition and oral cancer cell death induction.

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BACKGROUND A growing body of evidence shows that compounds of plant origin have the ability to prevent cancer. The fruit of gardenia, Gardenia jasminoides Ellis (Rubiaceae), has long been used as a food additive and herbal medicine, and its pharmacological actions, such as protective activity

Ascending colon cancer coincident with mesenteric phlebosclerosis associated with the long-term oral intake of Chinese herb containing gardenia fruit: A case report and literature review.

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Mesenteric phlebosclerosis is a recently discovered rare ischemic colon disease. The relationship between mesenteric phlebosclerosis and the use of herbal medicine containing gardenia fruit was recently reported. Although the relationship between colon cancer and mesenteric phlebosclerosis has not

Gastrointestinal absorption, antiproliferative and anti-inflammatory effect of the major carotenoids of Gardenia jasminoides Ellis on cancer cells.

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The gastrointestinal absorption of the main carotenoids present in Gardenia jasminoides Ellis, crocetin, crocin-1 and crocin-2, was assayed through transport studies on MKN-28 and Caco-2 cell lines. Overall, crocetin was the compound that presented the highest gastrointestinal transport efficiency.

Genipin, a constituent of Gardenia jasminoides Ellis, induces apoptosis and inhibits invasion in MDA-MB-231 breast cancer cells.

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Genipin, a constituent of Gardenia jasminoides Ellis, is used in the treatment of hepatic disorders and inflammatory diseases in traditional medicine. Although mounting evidence suggests an anti-tumor activity of genipin in several cancer cell systems, the inhibitory effect of genipin on the growth

Gardenoins E-H, cycloartane triterpenes from the apical buds of Gardenia obtusifolia.

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Four new cycloartane triterpenes, named gardenoins E-H (1-4), were isolated from the apical buds of Gardenia obtusifolia, together with five known cycloartanes. Only compound 1 displayed cytotoxicity against colon, hepatic and lung cancer cell lines.

seco-Cycloartane triterpenes from Gardenia aubryi.

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Three new 3,4-seco-cycloartanes, secaubryenol (1), secaubrytriol (2), and secaubryolide (3), were isolated from an exudate collected on the aerial parts of Gardenia aubryi, in addition to the known (24S)-cycloartane-24,25-diol-3-one, coccinetane A, herbacetin 3,8-dimethyl ether, hibiscetin

Cytotoxic 3,4-seco-cycloartane triterpenes from the exudate of Gardenia tubifera.

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Four new 3,4-seco-cycloartanes, gardenoins A-D (1-4), together with the known compound secaubryenol (5), were isolated from the exudate of Gardenia tubifera. The structures of 1-4 were elucidated on the basis of spectroscopic analysis. The cytotoxic activity of compounds 1-4 was evaluated against

Anticancer and antioxidant activities of methanol extracts and fractions of some Cameroonian medicinal plants.

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OBJECTIVE To obtain a scientific basis of the use of plant-derived preparations by many rural people in Cameroon, for their primary health care needs in the treatment of diseases such as cancer. METHODS The antiproliferative effect of 11 plants methanol crude extracts on four cancer cells using

Anti-inflammatory triterpenes from the apical bud of Gardenia sootepensis.

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Bioassay-guided fractionation of the dichloromethane extract from the apical bud of Gardenia sootepenesis Hutch. (Rubiaceae) led to the isolation of four new cycloartane triterpenes, sootepins F-I (1-4), along with four known derivatives (5-8). The structures of the new compounds were determined by

Dihydroxypentamethoxyflavone down-regulates constitutive and inducible signal transducers and activators of transcription-3 through the induction of tyrosine phosphatase SHP-1.

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Because constitutive activation of signal transducers and activators of transcription-3 (STAT3) has been linked with cellular transformation, survival, proliferation, chemoresistance, and angiogenesis of various tumor cells, agents that can suppress STAT3 activation have potential as cancer

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