gastrodin/hypoxia

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Protective effects of gastrodin on hypoxia-induced toxicity in primary cultures of rat cortical neurons.

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The phenolic glucoside gastrodin is the main component extracted from the rhizome of Gastrodia elata (Orchidaceae), a Chinese herbal medicine, which has long been used for treating dizziness, epilepsy, stroke and dementia. The present study aims to investigate the effect of gastrodin on

Gastrodin protects myocardial cells against hypoxia/reoxygenation injury in neonatal rats by inhibiting cell autophagy through the activation of mTOR signals in PI3K-Akt pathway.

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OBJECTIVE This study aimed to investigate the protective effect of gastrodin (GAS) on myocardial cells with hypoxia/reoxygenation (H/R) injury in neonatal rats and explore the underlying mechanism. METHODS Myocardial cells were extracted from neonatal rats and divided into six groups: control, H/R,

Gastrodin protects rat cardiomyocytes H9c2 from hypoxia-induced injury by up-regulation of microRNA-21.

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The in vivo protective role of gastrodin (GSTD) in myocardial infarction (MI) has been reported. However, the underlying mechanism remains unclear. Herein, we aimed to explore the effects of GSTD on hypoxia-injured H9c2 cells as well as the downstream microRNAs (miRNAs) and signaling

Gastrodin Protects Cardiomyocytes from Anoxia/Reoxygenation Injury by 14-3-3η.

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Gastrodin (GAS) is the major component isolated from the rhizome of the Chinese traditional medicinal herb "Tianma." Many clinical studies have found that GAS protects cardiomyocytes in cardiovascular diseases, although the effects and underlying mechanisms on cardiovascular anoxia/reoxygenation

Herbal compounds with special reference to gastrodin as potential therapeutic agents for microglia mediated neuroinﬂammation.

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BACKGROUND Activated microglia play a pivotal role neurodegenerative diseases by producing a variety of proinflammatory mediators including tumor necrosis factor-alpha (TNF-α), interleukin-1bea (IL-1β) and nitric oxide (NO) that are toxic to neurons and oligodendrocytes. METHODS In view of the

Effects of Gastrodin on BV2 Cells under Oxygen-glucose Deprivation and Its Mechanism

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Objective: Cerebrovascular disease is one of the major diseases that seriously harm human health currently. The purpose of this study is to find an effective treatment and clarify its mechanism of action to provide a new idea and drug

[Comparison studies on pharmacological properties of injectio gastrodia elata, gastrodin-free fraction and gastrodin].

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Injectio Gastrodia elata showed sedative effect on central nervous system with decrease of spontaneous motor activity and a prolonged pentobarbital sleeping time in mice. After administration of injectio Gastrodia, mice were found to be more resistant to hypoxia and nutrient blood flow in cardiac

The Role of Gastrodin on Hippocampal Neurons after N-Methyl-D-Aspartate Excitotoxicity and Experimental Temporal Lobe Seizures.

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Tian ma (Gastrodia elata, GE) is an ancient Chinese herbal medicine that has been suggested to be effective as an anticonvulsant and analgesic, and to have sedative effects against vertigo, general paralysis, epilepsy and tetanus. The primary active ingredient isolated from GE is termed gastrodin,

Gastrodin pretreatment alleviates myocardial ischemia/reperfusion injury through promoting autophagic flux.

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Gastrodin (GAS), a monomeric component exacted from the herb Gastrodia elata Bl, may have cardioprotective effects during injury caused by myocardial ischemia/reperfusion (I/R). For the significant role of autophagy in I/R process, we targeted to explore whether autophagy was contributing to the

Myocardial protection properties of parishins from the roots of Gastrodia elata Bl.

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Parishins, important constituents of Gastrodia elata (G. elata), are known to exhibit a number of biological and pharmacological properties. However, their role and mechanisms of action in myocardial ischemia are unknown. The present study investigated the potential protective effects and mechanisms

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