grandisin/neoplasms

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(-)-Grandisin form Cryptocarya crassinervia.

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The known lignan (-)-grandisin [1] has been isolated from Cryptocarya crassinervia by using the brine shrimp lethality test to direct the isolation; its structure and relative stereochemistry have been determined by ir, 1H nmr, ms, and X-ray crystallography as an all-trans alpha, alpha'-diaryl-beta,

Cytotoxicity and antiangiogenic activity of grandisin.

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OBJECTIVE The antitumoural properties of grandisin, a tetrahydrofuran neolignan from Piper solmsianum, were investigated by in-vitro and in-vivo assays using the Ehrlich ascites tumoural (EAT) model. METHODS Viability of the tumour cells was evaluated by Trypan blue exclusion and MTT methods, after

Grandisin, 2-methoxy 6,7,2',6'-tetrahydroxy flavanone 6-O-glucoside, from Cassia grandis leaves - antioxidant and cytotoxic activities.

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Chemical investigation of Cassia grandis leaves resulted in the isolation of the new 2-methoxy 6,7,2',6'-tetrahydroxy flavanone 6-O-β-glucoside together with the known flavonol glycosides, kaempferol-3-O-α-rhamnoside, and quercetin 3-O-α-rhamnoside. The structure assign ments were based on

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