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hexadecanol/hemorrhage
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Initial clinical trial of EXOSURF, a protein-free synthetic surfactant, for the prophylaxis and early treatment of hyaline membrane disease.
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EXOSURF is a protein-free surfactant composed of 85% dipalmitoylphosphatidylcholine, 9% hexadecanol, and 6% tyloxapol by weight. A single dose of 5 mL of EXOSURF per kilogram body weight, which gave 67 mg of dipalmitoylphosphatidylcholine per kilogram body weight, or 5 mL/kg air was given
Lysis of red blood cells and alveolar epithelial toxicity by therapeutic pulmonary surfactants.
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The risk of pulmonary hemorrhage is increased in extremely low birth weight infants treated with surfactant. The pathogenesis of this increased risk is far from clear. We tested whether exposure of cell membranes to surfactant may lead to increased membrane permeability, hypothesizing that this
Synthetic surfactant for respiratory distress syndrome in preterm infants.
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BACKGROUND
This section is under preparation and will be included in the next issue.
OBJECTIVE
To assess the effect of intratracheal administration of synthetic surfactant in premature newborns with established respiratory distress syndrome (RDS).
METHODS
Searches were made of the Oxford Database of
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