huntington disease/fatigue

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High-resolution magnetic resonance imaging sinc-interpolation-based subvoxel registration and semi-automated quantitative lateral ventricular morphology employing threshold computation and binary image creation in the study of fatty acid interventions in schizophrenia, depression, chronic fatigue syndrome and Huntington's disease.

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Serial high-resolution structural magnetic resonance imaging scans of the brain can now be precisely aligned, with six degrees of freedom (three mutually orthogonal translational and three rotational degrees of freedom around three mutually orthogonal axes), using a rigid-body subvoxel registration

Conditional BDNF release under pathological conditions improves Huntington's disease pathology by delaying neuronal dysfunction.

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BACKGROUND Brain-Derived Neurotrophic Factor (BDNF) is the main candidate for neuroprotective therapy for Huntington's disease (HD), but its conditional administration is one of its most challenging problems. RESULTS Here we used transgenic mice that over-express BDNF under the control of the Glial

Clozapine versus placebo in Huntington's disease: a double blind randomised comparative study.

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OBJECTIVE To establish the effect of the atypical neuroleptic clozapine on chorea, voluntary motor performance, and functional disability in patients with Huntington's disease. METHODS Thirty three patients with Huntington's disease participated in a double blind randomised trial. A maximum of 150

Mechanisms of altered skeletal muscle action potentials in the R6/2 mouse model of Huntington's disease

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Huntington's disease (HD) patients suffer from progressive and debilitating motor dysfunction for which only palliative treatment is currently available. Previously, we discovered reduced skeletal muscle Cl^- channel (ClC-1) and inwardly rectifying K⁺ channel (Kir) currents in

Myopathy as a first symptom of Huntington's disease in a Marathon runner.

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A semi professional marathon runner at risk for Huntington's disease (HD) (43 CAG repeats) developed signs of a slowly progressive myopathy with exercise-induced muscle fatigue, pain, elevated creatine kinase level, and worsening of his running performance many years before first signs of chorea

Circadian-based Treatment Strategy Effective in the BACHD Mouse Model of Huntington's Disease.

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Huntington's disease (HD) patients suffer from progressive neurodegeneration that results in cognitive, psychiatric, cardiovascular, and motor dysfunction. Disturbances in sleep-wake cycles are common among HD patients with reports of delayed sleep onset, frequent bedtime awakenings, and excessive

Blue light therapy improves circadian dysfunction as well as motor symptoms in two mouse models of Huntington's disease.

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Patients with Huntington's disease (HD) exhibit movement disorders, psychiatric disturbance and cognitive impairments as the disease progresses. Abnormal sleep/wake cycles are common among HD patients with reports of delayed sleep onset, fatigue during the day, and a delayed pattern of melatonin

Clinical aspects of coenzyme Q10: an update.

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The fundamental role of coenzyme Q(10) (CoQ(10)) in mitochondrial bioenergetics and its well-acknowledged antioxidant properties constitute the basis for its clinical applications, although some of its effects may be related to a gene induction mechanism. Cardiovascular disease is still the main

Retigabine (ASTA Medica).

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ASTA Medica is developing retigabine, a carbamic acid ethyl ester and a selective potassium channel opener, for the treatment of complex partial seizures. Phase II trials have commenced [249117], and a multicenter placebo-controlled dosage-finding study has begun in Europe and Australia [392702].

A novel XK gene mutation in a Taiwanese family with McLeod syndrome.

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McLeod syndrome is one subtype of rare neuroacanthocytosis syndromes characterized by misshapen red blood cells and progressive degeneration of the basal ganglia. It is an X-linked recessive disorder with mutation in the XK gene of the Kell blood group system with multisystem involvements.

Testosterone therapy in men with Parkinson disease: results of the TEST-PD Study.

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BACKGROUND Testosterone deficiency has been reported in patients with Parkinson disease (PD), Alzheimer disease, and Huntington disease. It is not known whether testosterone therapy (TT) in men with borderline hypogonadism and neurodegenerative diseases will be of substantial benefit. Previously, we

A comparison of mood and quality of life among people with progressive neurological illnesses and their caregivers.

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The current study was designed to investigate differences in mood and a range of QOL domains among 423 patients and 335 caregivers of people with motor neurone disease (MND), Huntington's disease (HD), Parkinson's, and multiple sclerosis (MS). Patients and caregivers completed an anonymous

A review of creatine supplementation in age-related diseases: more than a supplement for athletes.

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Creatine is an endogenous compound synthesized from arginine, glycine and methionine. This dietary supplement can be acquired from food sources such as meat and fish, along with athlete supplement powders. Since the majority of creatine is stored in skeletal muscle, dietary creatine supplementation

Tetrabenazine for the treatment of hyperkinetic movement disorders: a review of the literature.

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BACKGROUND Tetrabenazine (TBZ) is a monoamine storage inhibitor that was first introduced in the 1970s for the management of hyperkinetic movement disorders. Despite acceptance and usage worldwide, TBZ was only recently approved in the United States for the treatment of Huntington chorea. This

Depression's multiple comorbidities explained by (neuro)inflammatory and oxidative & nitrosative stress pathways.

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There is now evidence that depression, as characterized by melancholic symptoms, anxiety, and fatigue and somatic (F&S) symptoms, is the clinical expression of peripheral cell-mediated activation, inflammation and induction of oxidative and nitrosative stress (IO&NS) pathways and of central

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