indirubin/seizures

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Systematic pharmacological screens uncover novel pathways involved in cerebral cavernous malformations.

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Cerebral cavernous malformations (CCMs) are vascular lesions in the central nervous system causing strokes and seizures which currently can only be treated through neurosurgery. The disease arises through changes in the regulatory networks of endothelial cells that must be comprehensively understood

Identification of GSK-3 as a Potential Therapeutic Entry Point for Epilepsy.

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In view of the clinical need for new antiseizure drugs (ASDs) with novel modes of action, we used a zebrafish seizure model to screen the anticonvulsant activity of medicinal plants used by traditional healers in the Congo for the treatment of epilepsy, and identified a crude plant extract that

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