The invention relates to tricyclic 1-[(indol-3-yl)carbonyl]piperazine derivative having the general Formula (I) wherein X is CH.sub.2, O or S; R represents 1-3 substituents independently selected from H, (C.sub.1-4)alkyl, (C.sub.1-4)alkyloxy and halogen; R.sub.1 is (C.sub.5-8)cycloalkyl; R.sub.2 is H or (C.sub.1-4)alkyl; R.sub.3, R.sub.3', R.sub.4' R.sub.4', R.sub.5, R.sub.5' and R.sub.6' are independently hydrogen or (C.sub.1-4)-alkyl, optionally substituted with (C.sub.1-4)alkyloxy, OH or halogen; R.sub.6 is hydrogen or (C.sub.1-4)alkyl, optionally substituted with (C.sub.1-4)alkyloxy, OH or halogen; or R.sub.6 forms together with R.sub.7 a 4-7 membered saturated heterocyclic ring, optionally containing a further heteroatom selected from O and S; R.sub.7 forms together with R.sub.6 a 4-7 membered saturated heterocyclic ring, optionally containing a further heteroatom selected from O and S; or R.sub.7 is H, (C.sub.1-4)alkyl or (C.sub.3-5)cycloalkyl, the alkyl groups being optionally substituted with OH, halogen or (C.sub.1-4)alkyloxy; or a pharmaceutically acceptable salt thereof. The invention also relates to pharmaceutical compositions comprising said tricyclic 1-[(indol-3-yl)carbonyl]piperazine derivatives, and to the use of these derivatives in the treatment of pain, such as peri-operative pain, chronic pain neuropathic pain, cancer pain, and pain and spasticity associated with multiple sclerosis. ##STR00001##

N.V. Organon

Tricyclic 1-[(indol-3-yl)carbonyl]piperazine derivatives as cannabinoid CB1 receptor agonists

Disclosed herein are indole derivatives of the formula (I) ##STR00001## wherein each of the substitutents is given the definition as set forth in the specification and claims. Also disclosed are pharmaceutical compositions containing the indole derivatives and use of the derivatives for the treatment of pain.

indol/cannabis

Tricyclic 1-[(indol-3-yl)carbonyl]piperazine derivatives as cannabinoid CB1 receptor agonists

(Indol-3-yl) heterocycle derivatives as agonists of the cannabinoid CB1 receptor

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