Indol / inflammation

Substituted 1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl)acetic acid derivatives useful in the treatment of autoimmune and inflammatory disorders

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FIELD OF THE INVENTION The present invention relates to certain substituted 1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl)acetic acid derivatives of Formula (Ia) and pharmaceutically acceptable salts thereof, which exhibit useful pharmacological properties, for example, as agonists of the S1P1 receptor.

Substituted 1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl)acetic acid derivatives useful in the treatment of autoimmune and inflammatory disorders

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FIELD OF THE INVENTION The present invention relates to certain substituted 1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl)acetic acid derivatives of Formula (Ia) and pharmaceutically acceptable salts thereof, which exhibit useful pharmacological properties, for example, as agonists of the S1P1 receptor.

Substituted 1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl)acetic acid derivatives useful in the treatment of autoimmune and inflammatory disorders

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FIELD OF THE INVENTION The present invention relates to certain substituted 1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl)acetic acid derivatives of Formula (Ia) and pharmaceutically acceptable salts thereof, which exhibit useful pharmacological properties, for example, as agonists of the S1P1 receptor.

Anti-inflammatory 2-substituted-4-hydroxy-3-quinoline carboxamides

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STATE OF THE ART Related 3-quinoline carboxylic acid derivatives are described in commonly assigned U.S. Pat. Nos. 4,299,831, 4,397,856, 4,107,310 and 4,486,438. OBJECTS OF THE INVENTION It is an object of the invention to provide the novel 3-quinoline carboxylic acid derivatives of formula I and

Indol-3-yl derivatives

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The invention relates to indol-3-yl derivatives of the formula I ##STR2## in which A and B are each, independently of one another, O, S, NH, NR.sup.7, CO, CONH, NHCO or a direct bond, X is alkylene having 1 to 2 carbon atoms which is unsubstituted or monosubstituted by R.sup.4 or R.sup.5, or a

Bis-(1H-indol-3-yl)-maleinimide derivatives, processes for the preparation thereof and pharmaceutical compositions containing them

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BACKGROUND OF THE INVENTION Protein kinase C plays an outstanding part in the regulation of cellular processes which are closely connected with the physiological control of contractile, secretory and proliferative processes (see Y. Nishizuka, Nature, 308, 593-698/1984). The physiological activation

Bis-(1H-indol-3-YL)-maleinimide derivatives, processes for the preparation thereof and pharmaceutical compositions containing them

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BACKGROUND OF THE INVENTION Protein kinase C plays an outstanding part in the regulation of cellular processes which are closely connected with the physiological control of contractile, secretory and proliferative processes (see Y. Nishizuka, Nature, 308, 593-698/1984). The physiological activation

Crystalline 1H-imidazo[4,5-b]pyridin-5-amine, 7-[5-[(cyclohexylmethylamino)-methyl]-1H-indol-2-yl]-2-methyl, sulfate (1:1), trihydrate and its pharmaceutical uses

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FIELD OF INVENTION This invention relates to 1H-Imidazo[4,5-b]pyridin-5-amine, 7-[5-[(cyclohexylmethylamino)-methyl]-1H-indol-2-yl]-2-methyl, sulfate (1:1), trihydrate, (E6070), in its crystalline form. Possessing the ability to inhibit NF-.kappa.B activation through inhibition of the IKK.beta.

1-phenylpydrrolidin-2-ones and -thiones and 1-(4-pyridyl)pydrrolidin-2-ones and -thiones which are useful in the treatment of inflammatory disease

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FIELD OF THE INVENTION The present invention relates generally to a series of novel small molecules, their synthesis and their use in the treatment of inflammatory disease. BACKGROUND OF THE INVENTION Research spanning the last decade has helped to elucidate the molecular events attending cell-cell

Processes for the preparation of (R)-2-(7-4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydrocy- clopenta[B]indol-3-yl)acetic acid and salts thereof

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FIELD OF THE INVENTION The present invention relates to processes and intermediates useful in the preparation of (R)-2-(7-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydroc- yclopenta[b]indol-3-yl)acetic acid of Formula (Ia) or salts thereof, an S1P1 receptor modulator that is useful

Processes for the preparation of (R)-2-(7-4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydrocy- clopenta[B]indol-3-yl)acetic acid and salts thereof

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FIELD OF THE INVENTION The present invention relates to processes and intermediates useful in the preparation of of (R)-2-(7-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydroc- yclopenta[b]indol-3-yl)acetic acid of Formula (Ia) or salts thereof an S1P1 receptor modulator that is useful

Processes for the preparation of (R)-2-(7-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydroc- yclopenta[b]indol-3-yl)acetic acid and salts thereof

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FIELD OF THE INVENTION The present invention relates to processes and intermediates useful in the preparation of (R)-2-(7-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydroc- yclopenta[b]indol-3-yl)acetic acid of Formula (Ia) or salts thereof, an S1P1 receptor modulator that is useful

Amorphous (quinolin-2-ylmethoxy)indole compounds useful for treating inflammatory diseases

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BACKGROUND OF THE INVENTION EP 419,049, Prasit et al., Mar. 27, 1991, describes a series of quinolin-2-ylmethoxy indoles useful as inhibitors of leukotriene biosynthesis. Examples 1 and 1A therein teach the synthesis of 3-[N-(p-chlorobenzyl)-3-(t-butylthio)-5-(quinolin-2-ylmethoxy)indol-2-yl]-

Crystalline L-arginine salt of (R)-2-(7-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydroc- yclo-penta [b]indol-3-yl)acetic acid(Compund1) for use in SIPI receptor-associated disorders

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FIELD OF THE INVENTION The present invention relates to, inter alia, a novel crystalline free-plate habit or morphology, processes for preparing the crystalline free-plate habit, and uses of the crystalline free-plate habit of the L-arginine salt of

Crystalline L-arginine salt of (R)-2-(7-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydroc- yclo-penta [b]indol-3-yl)acetic acid(Compound 1) for use in SIPI receptor-associated disorders

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FIELD OF THE INVENTION The present invention relates to, inter alia, a novel crystalline free-plate habit or morphology, processes for preparing the crystalline free-plate habit, and uses of the crystalline free-plate habit of the L-arginine salt of

indol/inflammation

Substituted 1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl)acetic acid derivatives useful in the treatment of autoimmune and inflammatory disorders

Substituted 1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl)acetic acid derivatives useful in the treatment of autoimmune and inflammatory disorders

Substituted 1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl)acetic acid derivatives useful in the treatment of autoimmune and inflammatory disorders

Anti-inflammatory 2-substituted-4-hydroxy-3-quinoline carboxamides

Indol-3-yl derivatives

Bis-(1H-indol-3-yl)-maleinimide derivatives, processes for the preparation thereof and pharmaceutical compositions containing them

Bis-(1H-indol-3-YL)-maleinimide derivatives, processes for the preparation thereof and pharmaceutical compositions containing them

Crystalline 1H-imidazo[4,5-b]pyridin-5-amine, 7-[5-[(cyclohexylmethylamino)-methyl]-1H-indol-2-yl]-2-methyl, sulfate (1:1), trihydrate and its pharmaceutical uses

1-phenylpydrrolidin-2-ones and -thiones and 1-(4-pyridyl)pydrrolidin-2-ones and -thiones which are useful in the treatment of inflammatory disease

Processes for the preparation of (R)-2-(7-4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydrocy- clopenta[B]indol-3-yl)acetic acid and salts thereof

Processes for the preparation of (R)-2-(7-4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydrocy- clopenta[B]indol-3-yl)acetic acid and salts thereof

Processes for the preparation of (R)-2-(7-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydroc- yclopenta[b]indol-3-yl)acetic acid and salts thereof

Amorphous (quinolin-2-ylmethoxy)indole compounds useful for treating inflammatory diseases

Crystalline L-arginine salt of (R)-2-(7-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydroc- yclo-penta [b]indol-3-yl)acetic acid(Compund1) for use in SIPI receptor-associated disorders

Crystalline L-arginine salt of (R)-2-(7-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydroc- yclo-penta [b]indol-3-yl)acetic acid(Compound 1) for use in SIPI receptor-associated disorders

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