FIELD OF THE INVENTION
The present invention relates a new process to synthesize 1-((4-(4-Fluoro-2-methyl-1H-indol-5-yloxy)-6-methoxyquinolin-7-yloxy)meth- yl)cyclopropanamine (AL3818). A stable crystalline form of Al3818 has been prepared. Salts and their crystalline forms of AL3818 have been also
FIELD OF THE INVENTION
The present invention relates a new process to synthesize 1-((4-(4-Fluoro-2-methyl-1H-indol-5-yloxy)-6-methoxyquinolin-7-yloxy)meth- yl)cyclopropanamine (AL3818). A stable crystalline form of Al3818 has been prepared. Salts and their crystalline forms of AL3818 have been also
The invention relates to compounds of the formula I
##STR00001## in which Ar denotes a mono- or bicyclic aromatic homo- or heterocycle having 1 to 4 N, O and/or S atoms and 5 to 10 skeleton atoms, which may be unsubstituted or mono-, di- or trisubstituted by carbonyl oxygen, Hal, A, OH, OA,
This application is the U.S. National Phase of International Application PCT/NZ03/00094, filed 19 May 2003, which designated the U.S. PCT/NZ03/00094 claims priority to New Zealand Application No. 519031 filed 17 May 2002. The entire content of these applications are incorporated herein by
CROSS-REFERENCES TO RELATED APPLICATIONS
Incorporation by Reference to any Priority Applications
This application is the U.S. National Phase of International Application PCT/CN2015/096777, filed Dec. 9, 2015, which claims priority and interest of China Patent Application No. 201410749394.0 filed
BACKGROUND OF THE INVENTION
Compounds of formula I:
##STR00001## and pharmaceutically acceptable salts thereof, useful as protein kinase C inhibitors, were disclosed by Heath, et al., in European Patent Publication No. 817,627 (Heath).
Example #49 of Heath disclosed a free base compound of formula
BACKGROUND OF THE INVENTION
Field of the Invention
The invention generally relates to 5-alkylidenethiazolidine-2,4-dione and 3-alkylidene-1,3-dihydro-indol-2-one analogs and their use as selective sphingosine kinase 2 (SphK2) inhibitors in clinical implications. In particular, the invention provides
FIELD
The present invention relates to novel polymorphic salts of 8-fluoro-2-{4-[(methylamino)methyl]phenyl}-1,3,4,5-tetrahydro-6H-azepino[- 5,4,3-cd]indol-6-one, and to methods for their preparation. The invention is also directed to pharmaceutical compositions containing at least one polymorphic
FIELD
The present invention relates to novel polymorphic salts of 8-fluoro-2-{4-[(methylamino)methyl]phenyl}-1,3,4,5-tetrahydro-6H-azepino[- 5,4,3-cd]indol-6-one, and to methods for their preparation. The invention is also directed to pharmaceutical compositions containing at least one polymorphic
FIELD
The present invention relates to novel polymorphic salts of 8-fluoro-2-{4-[(methylamino)methyl]phenyl}-1,3,4,5-tetrahydro-6H-azepino[- 5,4,3-cd]indol-6-one, and to methods for their preparation. The invention is also directed to pharmaceutical compositions containing at least one polymorphic
FIELD OF THE INVENTION
The present invention relates to novel polymorphic and amorphous forms of the phosphate salt of 8-fluoro-2-{4-[(methylamino)methyl]phenyl}-1,3,4,5-tetrahydro-6H-azepino[- 5,4,3-cd]indol-6-one, and to methods for their preparation. The invention is also directed to
This application is the 35 U.S.C. .sctn.371 filing of PCT/EP2003/050226 filed Jun. 13, 2003.
The present invention relates to 1-[(indol-3-yl)carbonyl]piperazine derivatives, to pharmaceutical compositions comprising the same and to the use of these 1-[(indol-3-yl)carbonyl]piperazine derivatives as
The invention relates to indol-3-yl derivatives of the formula I ##STR2##
in which A and B are each, independently of one another, O, S, NH, NR.sup.7, CO, CONH, NHCO or a direct bond, X is alkylene having 1 to 2 carbon atoms which is unsubstituted or monosubstituted by R.sup.4 or R.sup.5, or a
BACKGROUND OF THE INVENTION
Protein kinase C plays an outstanding part in the regulation of cellular processes which are closely connected with the physiological control of contractile, secretory and proliferative processes (see Y. Nishizuka, Nature, 308, 593-698/1984). The physiological activation
BACKGROUND OF THE INVENTION
Protein kinase C plays an outstanding part in the regulation of cellular processes which are closely connected with the physiological control of contractile, secretory and proliferative processes (see Y. Nishizuka, Nature, 308, 593-698/1984). The physiological activation
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