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6 results
Benzofuran-3-yl(indol-3-yl) maleimides as potent GSK3 inhibitors
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BACKGROUND OF THE INVENTION
The search for new therapeutic agents has been greatly aided in recent years by better understanding of the structure of enzymes and other biomolecules associated with target diseases. One important class of enzymes that has been the subject of extensive study is the
Piperazino[1,2-a]indol-1-ones and [1,4]diazepino[1,2-a]indol-1-one
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BACKGROUND OF THE INVENTION
Neurogenesis occurs in the developing and adult brain. Conceptually, this process of neurogenesis can be divided into four steps: (i) proliferation of NSCs; (ii) neuronal fate determination of NSC; (iii) survival and maturation of new neurons; and (iv) functional
Method of treating of demyelinating diseases or conditions
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BACKGROUND OF THE INVENTION
Multiple sclerosis (MS) is a degenerative and inflammatory neurological disease that affects the central nervous system, and is associated with formation of neuronal plaques and impaired neuronal conduction due to demyelination (loss of myelin). Similarly, extensive
Method of treating of demyelinating diseases or conditions
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BACKGROUND OF THE INVENTION
Multiple sclerosis (MS) is a degenerative and inflammatory neurological disease that affects the central nervous system, and is associated with formation of neuronal plaques and impaired neuronal conduction due to demyelination (loss of myelin). Similarly, extensive
Method of treating demyelinating diseases or conditions
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BACKGROUND OF THE INVENTION
Multiple sclerosis (MS) is a degenerative and inflammatory neurological disease that affects the central nervous system, and is associated with formation of neuronal plaques and impaired neuronal conduction due to demyelination (loss of myelin). Similarly, extensive
Method of treating of demyelinating diseases or conditions
Only registered users can translate articles
Log In/Sign up
BACKGROUND OF THE INVENTION
Multiple sclerosis (MS) is a degenerative and inflammatory neurological disease that affects the central nervous system, and is associated with formation of neuronal plaques and impaired neuronal conduction due to demyelination (loss of myelin). Similarly, extensive
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