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Page 1 from 188 results
Indole derivatives useful to treat estrogen-related neoplasms and disorders
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BACKGROUND
The present invention relates to novel indole derivatives useful to down-regulate estrogen receptor expression and to treat neoplasms, especially estrogen-dependent neoplasms such as those associated with breast, ovarian, uterine and cervical tissue, and other disorders associated with
Method of inhibiting neoplastic cells with tetracyclic pyrido[3,4-B]indole derivatives
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TECHNICAL FIELD
This invention relates to a method for the selective inhibition of neoplastic cells, for example, for the treatment or prevention of precancerous lesions or other neoplasias in mammals.
BACKGROUND OF THE INVENTION
Each year in the United States alone, untold numbers of people develop
Use of derivatives of indoles for the treatment of cancer
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The present invention relates to derivatives of indoles and to their application in therapeutics, and in particular to treat the cancer.
Cell division is a highly dynamic process, which depends on the proper interaction of mitotic spindle microtubules (MTs) with chromosomes during mitosis. Because
Use of derivatives of indoles for the treatment of cancer
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The present invention relates to derivatives of indoles and to their application in therapeutics, and in particular to treat the cancer.
Cell division is a highly dynamic process, which depends on the proper interaction of mitotic spindle microtubules (MTs) with chromosomes during mitosis. Because
Functionalized thieno-indole derivatives for the treatment of cancer
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The present invention relates to new functionalized thieno-indole derivatives, methods for their preparation, pharmaceutical composition containing them and use thereof in treating certain mammalian tumors. The invention also relates to their use in the preparation of conjugates.
Lack of selectivity
Method of inhibiting neoplastic cells with indole derivatives
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TECHNICAL FIELD
This invention relates to a method for the selective inhibition of neoplastic cells, for example, for the treatment or prevention of precancerous lesions or other neoplasias in mammals.
BACKGROUND OF THE INVENTION
Each year in the United States alone, untold numbers of people develop
Method for inhibiting neoplastic cells with indole derivatives
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TECHNICAL FIELD
BACKGROUND OF THE INVENTION
Each year in the United States alone, untold numbers of people develop precancerous lesions, which is a form of neoplasia, as discussed below. Such lesions exhibit a strong tendency to develop into malignant tumors, or cancer. Such lesions include lesions
Method of inhibiting neoplastic cells with indole derivatives
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TECHNICAL FIELD
This invention relates to a method for the selective inhibition of neoplastic cells, for example, for the treatment or prevention of precancerous lesions or other neoplasias in mammals.
BACKGROUND OF THE INVENTION
Each year in the United States alone, untold numbers of people develop
Substituted indeno [1,2-b]indole derivatives as novel inhibitors of protein kinase CK2 and their use as tumor therapeutic agents, cytostatics and diagnostic aids
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The present invention relates to compounds of structure I, IA and II, to a process for the synthesis thereof and to pharmaceutical compositions comprising one or more of these compounds. The invention further relates to the use of these compounds for the manufacture of a medicament for the treatment
Derivatives of indole for the treatment of cancer, viral infections and lung diseases
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FIELD OF THE INVENTION
The present invention relates to derivatives of indoles and to their application as therapeutics, and in particular to treat the cancer.
BACKGROUND OF THE INVENTION
Cell division is a highly dynamic process, which depends on the proper interaction of mitotic spindle
Derivatives of indole for the treatment of cancer, viral infections and lung diseases
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FIELD OF THE INVENTION
The present invention relates to derivatives of indoles and to their application as therapeutics, and in particular to treat the cancer.
BACKGROUND OF THE INVENTION
Cell division is a highly dynamic process, which depends on the proper interaction of mitotic spindle
Indole compounds useful for the treatment of cancer
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BACKGROUND OF THE INVENTION
The invention was made with Government support under Grant No. 5ROI GM23200-24 awarded by the National Institute of Health. The Government has certain rights in the invention.
Prostate cancer is the second leading cause of cancer death among males in the United States. In
Indole compounds useful for the treatment of cancer
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BACKGROUND OF THE INVENTION
Prostate cancer is the second leading cause of cancer death among males in the United States. In 1998, an estimated 185,000 men were diagnosed with prostate cancer, and more than 39,000 men died of the disease. See, S. H. Landis et al., Cancer Statistics, CA Cancer J.
Indole compounds useful for the treatment of cancer
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BACKGROUND OF THE INVENTION
Prostate cancer is the second leading cause of cancer death among males in the United States. In 1998, an estimated 185,000 men were diagnosed with prostate cancer, and more than 39,000 men died of the disease. See, S. H. Landis et al., Cancer Statistics, CA Cancer J.
Pyrrolo[3,2-b-]-carbazoles and 1H[1]benzothieno [2,3-f] indoles having anti-tumor activity
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The present invention relates to heterocyclic compounds which have been found to have anti-tumour activity. More specifically, the invention concerns pyrrolo[3,2-b]-carbazoles and 1H-[1] benzothieno[2,3-f]indoles, methods for their preparation, pharmaceutical formulations containing them and their
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