indole/seizures

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Methods of treating seizure disorders

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TECHNICAL FIELD Methods of treating seizure disorders are provided. BACKGROUND Seizure disorders typically involve abnormal nerve cell activity in the brain, causing seizures which may be manifested by periods of unusual behavior, sensations, diminished consciousness and sometimes loss of

Pyridazino-indole derivatives

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This invention relates to a class of pyridazino[4,5-b]indole-1,4-dione derivatives which are substituted in the 2-position by an optionally substituted phenyl moiety. These compounds are selective non-competitive antagonists of N-methyl-D-aspartate (NMDA) receptors. More particularly, the class of

5-phenyl-1,2,3a,4,5,9b-hexahydro-3H-benz(e)indotes preparation and use thereof as drugs

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The present invention provides novel 5-phenyl-1,2,3a,4,5,9b-hexahydro-3H-benz[e]indoles, processes for preparing the same, therapeutic compositions containing same, and the use thereof in the treatment of disorders. The prior art discloses tricyclic pyrrolo[2,1-a]isoquinoline derivatives and

Anticonvulsive agents and uses thereof

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BACKGROUND OF THE INVENTION The present invention relates to a agents useful as excitatory amino acid antagonists. The quinoline and kynurenin derivatives of the present invention have affinity for the glycine binding site of the NMDA receptor. Compounds of the present invention should be usable for

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