insulin resistance/nicotine

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Long-term use of nicotine gum is associated with hyperinsulinemia and insulin resistance.

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BACKGROUND Insulin sensitivity and cardiovascular risk profile were examined in 20 healthy, nonobese, middle-aged men who were long-term users of nicotine-containing chewing gum and in 20 matched control subjects who did not use nicotine. RESULTS Long-term use of nicotine-containing chewing gum was

Prenatal and postnatal tobacco smoke exposure and development of insulin resistance in 10 year old children.

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In this study, we evaluated the association between prenatal and postnatal exposure to environmental tobacco smoke and the development of insulin resistance in 10 year old children. Fasting blood samples were collected from 470 children participating in two prospective birth cohorts. Of those 276

Acute effect of the transdermal administration of nicotine on insulin sensitivity in healthy individuals with and without a family history of type 2 diabetes mellitus in the first branch.

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The aim of this study was to evaluate the acute effect of the transdermal administration of nicotine on insulin sensitivity in healthy individuals with and without family histories of type 2 diabetes mellitus (DM2) in the first branch. A randomized, double-blind, cross-over, placebo-controlled

The Association Between Changes in Insulin Sensitivity and Consumption of Tobacco and Alcohol in Young Adults: Ordinal Logistic Regression Approach.

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BACKGROUND Reduced insulin sensitivity is one of the traditional risk factors for chronic diseases such as type 2 diabetes. Reduced insulin sensitivity leads to insulin resistance, which in turn can lead to the development of type 2 diabetes. Few studies have examined factors such as blood pressure,

Chronic exposure to nicotine enhances insulin sensitivity through α7 nicotinic acetylcholine receptor-STAT3 pathway.

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This study was to investigate the effect of nicotine on insulin sensitivity and explore the underlying mechanisms. Treatment of Sprague-Dawley rats with nicotine (3 mg/kg/day) for 6 weeks reduced 43% body weight gain and 65% blood insulin level, but had no effect on blood glucose level. Both insulin

Nicotine infusion acutely impairs insulin sensitivity in type 2 diabetic patients but not in healthy subjects.

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OBJECTIVE The aim of this study was to examine if an acute nicotine infusion alters insulin sensitivity to a similar degree in type 2 diabetic patients as in healthy control subjects. METHODS . Double-blind, cross-over, placebo-controlled, randomized experimental study. Nicotine 0.3 microg kg-1

Anti-inflammatory and antithrombotic effects of nicotine exposure in oral contraceptive-induced insulin resistance are glucocorticoid-independent.

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BACKGROUND Reports showed that estrogen-progestin oral contraceptive (COC) or tobacco smoking causes increased risk of cardiovascular diseases (CVD) in premenopausal women. Studies also suggest that nicotine, a major tobacco alkaloid, may worsen or improve atherothrombotic CVD. Altered hemorheology,

Anti-inflammatory and antithrombotic effects of nicotine exposure in oral contraceptive-induced insulin resistance are glucocorticoid-independent.

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Reports showed that estrogen-progestin oral contraceptive (COC) or tobacco smoking causes increased risk of cardiovascular diseases (CVD) in premenopausal women. Studies also suggest that nicotine, a major tobacco alkaloid, may worsen or improve atherothrombotic CVD. Altered

Factors influencing insulin resistance in relation to atherogenicity in mood disorders, the metabolic syndrome and tobacco use disorder.

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OBJECTIVE This study examines the effects of malondialdehyde (MDA) and uric acid on insulin resistance and atherogenicity in subjects with and without mood disorders, the metabolic syndrome (MetS) and tobacco use disorder (TUD). METHODS We included 314 subjects with depression and bipolar

Nicotine-mediated upregulation of microRNA-141 expression determines adipokine-intervened insulin resistance

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MicroRNAs (miRNAs) are non-coding RNAs that are associated with adipokine homeostasis and insulin resistance. Whereas, smoking can disturb metabolic homeostasis. Present study was aimed to investigate the level of miRNA-141 in experimental animal model that were exposed with graded doses of

Weight gain and insulin resistance during nicotine replacement therapy.

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BACKGROUND Although the cessation of smoking reduces the increased risk for ischemic heart disease, it is associated with marked weight gain and presumably insulin resistance, both of which heighten the risk of coronary heart disease. OBJECTIVE We investigated the isolated effect of nicotine on body

Long-term oral nicotine administration reduces insulin resistance in obese rats.

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This study aimed to investigate the effect of long-term oral nicotine administration on insulin resistance in an animal model of obesity. Eight-week-old male Zucker fatty rats (ZFRs) were administered nicotine tartrate dihydrate (4.6 mg/kg/day) in the drinking water. The control group was pair-fed.

Ameliorative effect of nicotine exposure on insulin resistance is accompanied by decreased cardiac glycogen synthase kinase-3 and plasminogen activator inhibitor-1 during oral oestrogen-progestin therapy.

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BACKGROUND Cigarette smoking is considered to be a major risk factor for the development of diabetes and cardiovascular disease. Oestrogen-progestin combined oral contraceptive (COC) use has been associated with adverse cardiometabolic events. OBJECTIVE We hypothesized that nicotine would ameliorate

Cigarette smoking, environmental tobacco smoke exposure and insulin sensitivity: the Insulin Resistance Atherosclerosis Study.

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OBJECTIVE To investigate whether active smoking and/or exposure to environmental tobacco smoke (ETS) is associated with insulin sensitivity. METHODS Insulin sensitivity and tobacco use history were measured in 1481 participants in the Insulin Resistance Atherosclerosis Study (IRAS). IRAS is a large

Calcium supplementation reverts central adiposity, leptin, and insulin resistance in adult offspring programed by neonatal nicotine exposure.

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Obesity is a worldwide epidemic. Calcium influences energy metabolism regulation, causing body weight loss. Because maternal nicotine exposure during lactation programs for obesity, hyperleptinemia, insulin resistance (IR), and hypothyroidism, we decided to evaluate the possible effect of dietary

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