isoquinoline/atrophy

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4-hydroxy-isoquinoline compounds as HIF hydroxylase inhibitors

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BACKGROUND 1. Field The present invention relates to novel compounds and compositions capable of inhibiting PHD1 enzyme activity selectively over other isoforms, for example, PHD2 and/or PHD3 enzymes. Selective inhibition of PHD1 has useful therapeutic applications. Therefore, methods of using the

Isoquinoline derivatives

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The present invention relates to the use of compounds of general formula ##STR00002## wherein R.sup.1 is phenyl or pyridinyl, which are optionally substituted by halogen, cyano or lower alkyl substituted by halogen, or is dihydro-pyran-4-yl; R.sup.2 is hydrogen or lower alkyl; R.sup.3 is

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