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isoquinoline/inflammation
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Quinoline and isoquinoline derivatives, a process for their production and their use as inflammation inhibitors
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The invention relates to quinoline and isoquinoline derivatives, a process for their production and their use as inflammation inhibitors.
From the prior art of DE 100 38 639 and WO02/10143, inflammation inhibitors of the general formula ##STR2##
are known, whereby the Ar radical comprises
Quinoline and isoquinoline derivatives, a process for their production and their use as inflammation inhibitors
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The invention relates to quinoline and isoquinoline derivatives, a process for their production and their use as inflammation inhibitors.
From the prior art of DE 100 38 639 and WO02/10143, inflammation inhibitors of the general formula
##STR00002## are known, whereby the Ar radical comprises
Quinoline and isoquinoline derivatives, a process for their production and their use as inflammation inhibitors
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The invention relates to quinoline and isoquinoline derivatives, a process for their production and their use as inflammation inhibitors.
From the prior art of DE 100 38 639 and WO02/10143, inflammation inhibitors of the general formula
##STR00002## are known, whereby the Ar radical comprises
5-substituted quinoline and isoquinoline derivatives, a process for their production and their use as anti-inflammatory agents
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The invention relates to 5-substituted quinoline and isoquinoline derivatives, a process for their production and their use as anti-inflammatory agents.
From the prior art WO03/082827, anti-inflammatory agents of general formula
##STR00002## are known, whereby the Q-radical comprises quinoline and
1-Phenyl isoquinoline-5-acetic acid compounds and analgesic compositions thereof
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This invention relates to novel isoquinoline derivatives. More specifically, this invention relates to novel isoquinoline derivatives having a lower alkyl group, a lower cycloalkyl group or a phenyl group at the 1-position of the isoquinoline nucleus and a carboxyalkyl or cyanoalkyl group or a group
1-aryl-4-substituted isoquinolines
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FIELD OF THE INVENTION
This invention relates generally to 1-aryl-4-substituted isoquinolines that act as modulators of mammalian complement C5a receptors, and to pharmaceutical compositions comprising such modulators. The present invention further relates to the use of such modulators in treating a
Isoquinoline derivatives
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The invention relates to compounds of the general formula I
##STR00001## in which X is H, --C(.dbd.NR.sup.3)--NHR.sup.4 or Het,
##STR00002## Y is --(CH2)m-, Z is NH or CH.sub.2, R.sup.1 and R.sup.5 are each, independently of one another, H, A, OH, OA, arylalkyl, Hal, --CO--A, CN, NO.sub.2,
Pyridine, quinoline, and isoquinoline N-oxides as kinase inhibitors
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FIELD OF THE INVENTION
This invention relates to urea compounds containing a pyridine, quinoline, or isoquinoline functionality, which are useful in the treatment of:
(i) raf mediated diseases, for example, cancer,
(ii) p38 mediated diseases such as inflammation and osteoporosis, and
(iii) VEGF
Pyridine, quinoline, and isoquinoline N-oxides as kinase inhibitors
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FIELD OF THE INVENTION
This invention relates to urea compounds containing a pyridine, quinoline, or isoquinoline functionality, which are useful in the treatment of:
(i) raf mediated diseases, for example, cancer,
(ii) p38 mediated diseases such as inflammation and osteoporosis, and
(iii) VEGF
Naphthol, quinoline and isoquinoline-derived urea modulators of vanilloid VR1 receptor
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STATEMENT REGARDING FEDERALLY SPONSORED RESEARCH OR DEVELOPMENT
The research and development of the invention described below was not federally sponsored.
BACKGROUND OF THE INVENTION
This invention is directed to novel vanilloid receptor VR1 ligands. More particularly, this invention relates to
Isoquinoline derivatives
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This invention relates to new therapeutically useful isoquinoline derivatives, to processes for their preparation and pharmaceutical compositions containing them.
The new isoquinoline derivatives of the present invention are those of the general formula: ##STR2## wherein the symbol A represents a
Isoquinoline derivatives
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This invention relates to new therapeutically useful isoquinoline derivatives, to processes for their preparation and pharmaceutical compositions containing them.
In the specification of our U.S. Patent Application Ser. No. 958,617 filed Nov. 8, 1978 now U.S. Pat. No. 4,189,480 (and also in British
Antiviral isoquinoline derivatives
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DESCRIPTION
This invention relates to new therapeutically useful isoquinoline derivatives, to processes for their preparation and to pharmaceutical compositions containing them.
In the specification of our U.S. Pat. No. 4,153,698 (granted May 8, 1979) we have described and claimed isoquinoline
Isoquinoline derivatives and pharmaceutical compositions containing them
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This invention relates to new therapeutically useful isoquinoline derivatives, to processes for their preparation and to pharmaceutical compositions containing them.
The new isoquinoline derivatives of the present invention are those of the general formula: ##STR1## wherein R represents a straight-
Heterocyclic amine-boranes, and method of inhibiting DNA topoisomerase activity and/or combatting inflammation, hyperlipidemia, and/or neoplasia using amine-borane compounds
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BACKGROUND OF THE INVENTION
1. Field of the Invention
The present invention relates to amine-borane compounds, including novel heterocyclic amine-boranes, and to a method of inhibiting enzyme (e.g., DNA topoisomerase) activity and/or combatting inflammation, hypolipidemia and/or neoplasia using
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