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isoquinoline/obesity
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6-and 7-amino isoquinoline compounds and methods for making and using the same
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FIELD OF THE INVENTION
The present invention relates to 6- and 7-aminoisoquinoline compounds that affect the function of kinases in a cell and that are useful as therapeutic agents or with therapeutic agents. In particular, these compounds are useful in the treatment of eye diseases such as glaucoma
6-and 7-amino isoquinoline compounds and methods for making and using the same
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FIELD OF THE INVENTION
The present invention relates to 6- and 7-aminoisoquinoline compounds that affect the function of kinases in a cell and that are useful as therapeutic agents or with therapeutic agents. In particular, these compounds are useful in the treatment of eye diseases such as glaucoma
Substituted 6, 7-dialkoxy-3-isoquinoline derivatives as inhibitors of phosphodiesterase 10 (PDE 10A)
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BACKGROUND OF THE INVENTION
Phosphodiesterases (PDEs) are a class of intracellular enzymes involved in the hydrolysis of the nucleotides cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphates (cGMP) into their respective nucleotide monophosphates. The cyclic nucleotides cAMP and
Substituted 6, 7-dialkoxy-3-isoquinoline derivatives as inhibitors of phosphodiesterase 10 (PDE 10A)
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BACKGROUND OF THE INVENTION
Phosphodiesterases (PDEs) are a class of intracellular enzymes involved in the hydrolysis of the nucleotides cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphates (cGMP) into their respective nucleotide monophosphates. The cyclic nucleotides cAMP and
Isoquinoline derivatives useful as inhibitors of diacylglyceride O-acyltransferase 2
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FIELD OF THE INVENTION
The present invention is directed to tetrahydroisoquinoline derivative compounds which inhibit diacylglyceride O-acyltransferase 2 ("DGAT2"), and their use for preventing, treating or acting as a remedial agent for hepatic steatosis, type-2 diabetic mellitus, obesity,
Serotonin receptor binding benzo[e]isoindoles and benzo[h]isoquinolines
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BACKGROUND OF THE INVENTION
Serotonin is a vasoconstrictor and neurotransmitter present in the brain, intestinal tissue and blood platelets. Regulation of the binding of serotonin can provide a method of treatment and prevention of a variety of illnesses including central nervous disorders,
Pyrrolo(oxo)isoquinolines as 5HT ligands
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BACKGROUND
The neurotransmitter/hormone serotonin (5-hydroxytryptamine, 5-HT) regulates many physiological processes via a group of at least 14 distinct receptors that are organized into 7 subfamilies (Hoyer, D., et al., Pharmacol. Rev., 46, 1994). The 5-HT.sub.2 subfamily is composed of the
Isoquinoline derivatives as MGAT2 inhibitors
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TECHNICAL FIELD
The present invention is directed to isoquinoline derivative compounds. Specifically, the compounds act as monoacylglycerol acyltransferase type 2 (hereinafter also referred to as "MGAT2"), and can be useful in preventing, treating or acting as a remedial agent for hyperlipidemia,
Diacylglycerol acyltransferase inhibitors
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FIELD OF THE INVENTION
The invention involves inhibitors of diacylglycerol acyltransferase. The inhibitors are useful for the treatment of diseases such as obesity, type II diabetes mellitus, dyslipidemia and metabolic syndrome.
All documents cited or relied upon below are expressly incorporated
6-aminoisoquinoline compounds
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FIELD OF THE INVENTION
The present invention relates to 6-aminoisoquinoline compounds that affect the function of kinases in a cell and that are useful as therapeutic agents or with therapeutic agents. In particular, these compounds are useful in the treatment of eye diseases such as glaucoma and
6-aminoisoquinoline compounds
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FIELD OF THE INVENTION
The present invention relates to 6-aminoisoquinoline compounds that affect the function of kinases in a cell and that are useful as therapeutic agents or with therapeutic agents. In particular, these compounds are useful in the treatment of eye diseases such as glaucoma and
6-aminoisoquinoline compounds
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FIELD OF THE INVENTION
The present invention relates to 6-aminoisoquinoline compounds that affect the function of kinases in a cell and that are useful as therapeutic agents or with therapeutic agents. In particular, these compounds are useful in the treatment of eye diseases such as glaucoma and
6-aminoisoquinoline compounds
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FIELD OF THE INVENTION
The present invention relates to 6-aminoisoquinoline compounds that affect the function of kinases in a cell and that are useful as therapeutic agents or with therapeutic agents. In particular, these compounds are useful in the treatment of eye diseases such as glaucoma and
6-aminoisoquinoline compounds
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FIELD OF THE INVENTION
The present invention relates to 6-aminoisoquinoline compounds that affect the function of kinases in a cell and that are useful as therapeutic agents or with therapeutic agents. In particular, these compounds are useful in the treatment of eye diseases such as glaucoma and
6-aminoisoquinoline compounds
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FIELD OF THE INVENTION
The present invention relates to 6-aminoisoquinoline compounds that affect the function of kinases in a cell and that are useful as therapeutic agents or with therapeutic agents. In particular, these compounds are useful in the treatment of eye diseases such as glaucoma and
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