isoquinoline/stroke

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Isoquinoline-1,3,4-trione compounds, the synthetic method and the use thereof

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CLAIM OF PRIORITY This claims priority under 35 U.S.C. .sctn.120 to International Patent Application Serial No. PCT/CN2004/000567 filed on May 31, 2004, which claims priority to People's Republic of China Patent Application Serial No. CN 03129250.X filed on Jun. 13, 2003 the teachings of both

Isoquinoline derivatives

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TECHNICAL FIELD The present invention relates to new isoquinoline derivatives and their pharmaceutically acceptable acid addition salts. The derivatives of the present invention have inhibitory activity on neuronal cell death (apoptotic cell death-type) caused by excessive apoptosis in a nervous

Serotonin receptor binding benzo[e]isoindoles and benzo[h]isoquinolines

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BACKGROUND OF THE INVENTION Serotonin is a vasoconstrictor and neurotransmitter present in the brain, intestinal tissue and blood platelets. Regulation of the binding of serotonin can provide a method of treatment and prevention of a variety of illnesses including central nervous disorders,

Isoquinoline derivatives

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The present invention relates to the use of compounds of general formula ##STR00002## wherein R.sup.1 is phenyl or pyridinyl, which are optionally substituted by halogen, cyano or lower alkyl substituted by halogen, or is dihydro-pyran-4-yl; R.sup.2 is hydrogen or lower alkyl; R.sup.3 is

Tetrahydro-isoquinolines

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BACKGROUND OF THE INVENTION HDM2 plays a central role in regulating and influencing important cell-signaling pathways. HDM2 is known to interact with a range of different proteins that influence cellular apoptosis, proliferation and survival. Thus, amongst other proteins, HDM2 binds to the tumor

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