keratoconjunctivitis sicca/adenosine

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Efficacy of Trabodenoson in a Mouse Keratoconjunctivitis Sicca (KCS) Model for Dry-Eye Syndrome.

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UNASSIGNED To determine the efficacy of trabodenoson, an adenosine mimetic with highly selective adenosine A1 receptor binding properties, in a preclinical mouse model for dry-eye disease. UNASSIGNED Dry-eye disease was induced in adult male C57BL/6 mice using a combination of desiccating

Stimulation of tear secretion by topical agents that increase cyclic nucleotide levels.

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The authors examined the effect of topical application of agents known to increase cyclic nucleotide levels on tear secretion by accessory lacrimal gland tissue in their rabbit model for keratoconjunctivitis sicca (KCS). Tear secretion was studied by changes in tear film osmolarity and tear volume

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