The symptom intensity and mortality of human diseases, conditions, and syndromes exhibit diurnal or 24 h patterning, e.g., skin: atopic dermatitis, urticaria, psoriasis, and palmar hyperhidrosis; gastrointestinal: esophageal reflux, peptic ulcer (including perforation and hemorrhage), cyclic
In 43 women and 3 men suffering from primary Sjögren's syndrome pulmonary function was correlated to various clinical, haematological and serological disease activity parameters. Primary Sjögren's syndrome was defined as the presence of keratoconjunctivitis sicca and xerostomia, in the absence of
Sjögren's syndrome is currently considered an "autoimmune epithelitis," as exocrine glands, especially salivary and lacrimal, are progressively destructed by an immune-mediated process associated with specific serum autoantibodies and local lymphocyte infiltrate. Xerostomia remains a key complain in
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