leukoaraiosis/albumin

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Brain microangiopathy and macroangiopathy share common risk factors and biomarkers.

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OBJECTIVE Besides carotid or cardiac embolism, stroke can occur via microangiopathy (small arterial disease [SAD]) and macroangiopathy (intracranial atherosclerotic stroke [ICAS]) of the intracranial vasculature. There have been efforts to identify risk factors specific to microangiopathy and

Micro- and macroalbuminuria predict hemorrhagic transformation in acute ischemic stroke.

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BACKGROUND Hemorrhagic transformation (HT) after cerebral ischemia seems to be related to the endothelial disruption secondary to the ischemic process. Albuminuria has recently been found to be a marker of chronic endothelial damage. OBJECTIVE To investigate the relationship between albuminuria and

Blood-brain barrier permeability abnormalities in vascular cognitive impairment.

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OBJECTIVE Disruption of the blood-brain barrier has been proposed to be important in vascular cognitive impairment. Increased cerebrospinal fluid albumin and contrast-enhanced MRI provide supporting evidence, but quantification of the blood-brain barrier permeability in patients with vascular

Matrix metalloproteinases are associated with increased blood-brain barrier opening in vascular cognitive impairment.

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OBJECTIVE Subcortical ischemic vascular disease (SIVD) is a major form of vascular cognitive impairment (VCI) due to small vessel disease. Matrix metalloproteinases (MMPs) are neutral proteases that disrupt the blood-brain barrier and degrade myelin basic protein under conditions of

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