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ligustrazine/atrophy
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14 results
[Effect of Ligustrazine on expressions of FoXO3a, MAFbx, and MuRF1 in denervated skeletal muscle atrophy rats].
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OBJECTIVE
To investigate the effect of Ligustrazine on the expressions of FoXO3a, MAFbx, and MuRF1 in denervated skeletal muscle atrophy rats.
METHODS
Fifty-four 8-week-old female Sprague Dawley rats were randomly divided into 3 groups: normal control group (group A, n = 6), denervated control group
Ligustrazine Prevents Intervertebral Disc Degeneration via Suppression of Aberrant TGFβ Activation in Nucleus Pulposus Cells.
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Objectives
Aberrant transforming growth factor β (TGFβ) activation is detrimental to both nucleus pulposus (NP) cells and cartilage endplates (CEPs), which can lead to intervertebral disc degeneration (IDD). Ligustrazine (LIG) reduces the expression of inflammatoryProtective effect of ligustrazine on lumbar intervertebral disc degeneration of rats induced by prolonged upright posture.
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Most chronic low back pain is the result of degeneration of the lumbar intervertebral disc. Ligustrazine, an alkaloid from Chuanxiong, reportedly is able to relieve pain, suppress inflammation, and treat osteoarthritis and it has the protective effect on cartilage and chondrocytes. Therefore, we
[Effects of Ligustrazine and Radix Astragali on activities of myosin adenosine triphosphatase of soleus muscle and muscle atrophy in tail-suspended rats].
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OBJECTIVE
To study the effects of Ligustrazine (Lig) and Radix Astragali (Rad) on activities of myosin adenosine triphosphatase (mATPase) of soleus muscle and atrophy in tail-suspended rat.
METHODS
Weightlessness was simulated by tail suspension in female rats. The activities of mATPase of
[Changes of the brain NSE, S100 and effect of ligustrazine in rats of chronic hypoxia and hypercapnia].
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OBJECTIVE
To investigate the changes of the brain NSE, S100 and ultrastructure and effect of ligustrazine in rats of chronic hypoxia and hypercapnia.
METHODS
Thirty rats were randomly divided into three groups: control group (A), hypoxia hypercapnia group (B), hypoxia hypercapnia added ligustrazine
[Effect of Ligusticum and its two main components on muscle atrophy in a hind limb unloaded rat model].
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OBJECTIVE
To study the effects of Ligusticum and its two components (Sodium Ferulate and Ligustrazine as main efficacy components in Ligusticum for invigorating blood circulation) on muscle atrophy in a hind limb unloaded rat model.
METHODS
The tail-suspended rats were subjected to a 14-days disuse,
Ligustrazine-Oleanolic Acid Glycine Derivative, G-TOA, Selectively Inhibited the Proliferation and Induced Apoptosis of Activated HSC-T6 Cells.
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Hepatic fibrosis is a naturally occurring wound-healing reaction, with an imbalance of extracellular matrix (ECM) during tissue repair response, which can further deteriorate to hepatocellular carcinoma without timely treatment. Inhibiting activated hepatic stellate cell (HSC) proliferation and
Ligustrazine ameliorates acute kidney injury through downregulation of NOD2‑mediated inflammation.
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Ligustrazine has been used to alleviate clinical acute kidney injury (AKI); however, the underlying molecular mechanisms are poorly understood. In order to further elucidate the molecular mechanism underlying its occurrence, the role of nucleotide‑binding oligomerization domain‑containing 2 (NOD2)
Ligustrazine Inhibits Cartilage Endplate Hypertrophy via Suppression of TGF-β1.
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CEP hypertrophy is one of the characteristics of intervertebral disc degeneration (IDD). LIG exerts a protective effect on IDD in animal model. The effect of LIG on CEP hypertrophy is further investigated in the present study. Cells were isolated from hypertrophic samples obtained from patients
[Effects of three Chinese traditional drugs on afferent discharge from single muscle spindle in toads].
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OBJECTIVE
To shed some light on treatment of muscle atrophy through testing the effects of several Chinese traditional drugs that can invigorate blood circulation on the afferent discharge of muscle spindle.
METHODS
Single muscle spindle was isolated from sartorius muscle of toad. Afferent discharge
Neural protection by naturopathic compounds-an example of tetramethylpyrazine from retina to brain.
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Given the advantages of being stable in the ambient environment, being permeable to the blood-brain and/or blood-eye barriers and being convenient for administration, naturopathic compounds have growingly become promising therapeutic candidates for neural protection. Extracted from one of the most
Muscle composition after 14-day hindlimb unloading in rats: effects of two herbal compounds.
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OBJECTIVE
We studied the potential of two herbal compounds (HC-1 and HC-2) in different dosages (HC-1, containing ligustrazine; HC-2, containing radix astragali) as a countermeasure against muscle atrophy in a hindlimb unloading rat model. Soleus muscle weight, fiber type distribution,
[Changes in gerbil brain tissue following cerebral ischemia and postischemic reperfusion and studies of the effects of the Chinese drugs].
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With the animal model of cerebral ischemia and reperfusion, we conducted experiments on such model to study the effects of Ligustrazine(LZ) and Salvia Miltirrhizae(SM). The results obtained are as follows: (1) The ischemic brain showed hyperperfusion (congestion period) after 10 min reperfusion
Erratum: Neural protection by naturopathic compounds-an example of tetramethylpyrazine from retina to brain.
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Given the advantages of being stable in the ambient environment, being permeable to the blood-brain and/or blood-eye barriers and being convenient for administration, naturopathic compounds have growingly become promising therapeutic candidates for neural protection. Extracted from one of the most
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