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lipoxygenase/neoplasms
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Page 1 from 27 results
Method for induction of tumor cell apoptosis with chemical inhibitors targeted to 12-lipoxygenase
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BACKGROUND OF THE INVENTION
1. Field of the Invention
The present invention relates to methods for the identification and use of chemical compounds that can selectively kill tumor cells by inducing cell apoptosis. Apoptosis is a natural process for normal cells and means programmed cell death. Tumor
Use of lipoxygenase inhibitors and PPAR ligands as anti-cancer therapeutic and intervention agents
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FIELD OF THE INVENTION
The present invention is in the field of the prevention and treatment of cancer. More specifically, this invention relates to the use of 5-lipoxygenase inhibitors and PPAR ligands or derivatives thereof in preventing and treating cancer.
BACKGROUND OF THE INVENTION
The
Use of lipoxygenase inhibitors as anti-cancer therapeutic and intervention agents
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FIELD OF THE INVENTION
This invention is in the field of the prevention and treatment of cancer. More specifically, this invention relates to the use of 5-lipoxygenase inhibitors or derivatives thereof in preventing and treating cancer.
BACKGROUND OF THE INVENTION
Arachidonic acid (AA) is a
1,2,4-tribsubstituted benzenes as inhibitors of 15-lipoxygenase
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FIELD OF THE INVENTION
The present invention provides inhibitors of the enzyme 15-lipoxygenase, pharmaceutical compositions comprising said inhibitors, and methods of treating diseases responsive to inhibition of 15-lipoxygenase.
BACKGROUND OF THE INVENTION
Hypercholesterolemia can induce monocytes
4-((2-hydroxy-3-methoxybenzyl)amino)benzenesulfonamide derivatives as potent and selective inhibitors of 12-lipoxygenase
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BACKGROUND OF THE INVENTION
Lipoxygenases are a class of non-heme iron-containing enzymes which regio- and stereospecifically oxidize polyunsaturated fatty acid substrates such as arachidonic acid (AA) and linoleic acid (LA). (Solomon, et al. Chem. Biol. 1997, 4, 795-808; Brash, J. Biol. Chem. 1999,
Method for inhibiting 15-lipoxygenase with fermented Glycine max (L.) extract
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RELATED APPLICATION(S)
The present application is a continuation in part application of U.S. patent application Ser. No. 09/812,579, filed on Mar. 21, 2001, now abandoned.
TECHNICAL FIELD
This invention relates to a use of a fermented Glycine max (L.) extract in inhibiting 15-lipoxygenase,
5-lipoxygenase inhibitors
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FIELD OF THE INVENTION
The present invention relates to 5-lipoxygenase inhibitors. Compounds disclosed herein can be useful in the treatment of bronchial asthma , chronic obstructive pulmonary disorder, arthritis, type I diabetes, multiple sclerosis, allograft rejection, psoriasis, inflammatory
Inhibitors of human 12/15-lipoxygenase
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TECHNICAL FIELD
The present invention relates generally to inhibition of 12/15-lipoxygenase, treatment of a condition involving 12/15-lipoxygenase including, but not limited to, strokes, periventricular leukomalacia, cardiac arrest with resuscitation, atherosclerosis, Parkinson's disease,
Human leukocyte 12-lipoxygenase and its role in the pathogenesis of disease states
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TECHNICAL FIELD
This invention pertains to a human leucocyte type of 12-LO and its role in the pathogenesis of several major disease states.
ABBREVIATIONS AA = Arachidonic acid AII = Angiotensin II EGF = Epidermal Growth Factor EN = Fibronectin GAPDH = Glyceraldehyde-3-phosphate dehydrogenase GF =
Human leukocutye 12-lipoxygenase and its role in the pathogenesis of disease states
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TECHNICAL FIELD
This invention pertains to a human leucocyte type of 12-LO and its role in the pathogenesis of several major disease states.
ABBREVIATIONS AA=Arachidonic acid AII=Angiotensin II EGF=Epidermal Growth Factor FN=Fibronectin GAPDH=Glyceraldehyde-3-phosphate dehydrogenase GF=Growth Factor
Human leukocyte 12-lipoxygenase and its role in the pathogenesis of disease states
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TECHNICAL FIELD
This invention pertains to a human leucocyte type of 12-LO and its role in the pathogenesis of several major disease states.
ABBREVIATIONS AA = Arachidonic acid AII = Angiotensin II EGF = Epidermal Growth Factor FN = Fibronectin GAPDH = Glyceraldehyde-3-phosphate dehydrogenase GF =
Formulation of dual cycloxygenase (COX) and lipoxygenase (LOX) inhibitors for mammal skin care
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FIELD OF THE INVENTION
This invention relates generally to a method for the prevention and treatment of diseases and conditions mediated by cyclooxygenase (COX) and lipoxygenase (LOX). Specifically, the present invention relates to a novel composition of matter comprised of a mixture of a blend of
Formulation of dual cycloxygenase (COX) and lipoxygenase (LOX) inhibitors for mammal skin care
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FIELD OF THE INVENTION
This invention relates generally to a method for the prevention and treatment of diseases and conditions mediated by cyclooxygenase (COX) and lipoxygenase (LOX). Specifically, the present invention relates to a novel composition of matter comprised of a mixture of a blend of
Quinazolinone-based oncogenic-RAS-selective lethal compounds and their use
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FIELD OF INVENTION
The present invention provides, inter alia, quinazolinone-based oncogenic-RAS-selective lethal compounds and compositions containing such compounds. Methods for using such compounds or compositions are also provided.
BACKGROUND OF THE INVENTION
Synthetic lethality describes a
Carbonyl erastin analogs and their use
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FIELD OF INVENTION
The present invention provides, inter alia, carbonyl erastin analogs and compositions containing such compounds. Methods for using such compounds or compositions are also provided.
BACKGROUND OF THE INVENTION
Synthetic lethality describes a genetic interaction in which
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