lysophosphatidylcholine/diarrhea

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[Synthesis of prostaglandins E2 and F2alpha and quantitative changes in lipids in small intestinal mucosa in normal piglets and in piglets with diarrhea].

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Small intestine mucose inflammation and diarrhea syndrome in piglets affected by salmonella endotoxin enhanced prostaglandin E2 synthesis and decreased prostaglandin F2 alpha synthesis. Under these conditions the share of free cholesterol decreased and the share of diacylglycerols increased in total

Comparison of the systemic phospholipid profile in dogs diagnosed with idiopathic inflammatory bowel disease or food-responsive diarrhea before and after treatment.

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Inflammatory bowel disease (IBD) and food-responsive diarrhea (FRD) are common chronic enteropathies in dogs, of which the exact pathogenesis has not been fully understood. In people dyslipidemia has been reported in patients with IBD, and potential therapeutic benefits of

Deficiency of alkaline SMase enhances dextran sulfate sodium-induced colitis in mice with upregulation of autotaxin.

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Intestinal alkaline SMase (Alk-SMase) cleaves phosphocholine from SM, platelet-activating factor (PAF), and lysophosphatidylcholine. We recently found that colitis-associated colon cancer was 4- to 5-fold enhanced in Alk-SMase KO mice. Here, we further studied the pathogenesis of colitis induced by

Plasma metabolomic profiles and immune responses of piglets after weaning and challenge with E. coli.

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BACKGROUND The processes of weaning and exposure to pathogenic bacteria induce stress responses, which may alter the metabolism. In this study, we investigated the changes in plasma metabolites and immune responses in piglets in response to the stress induced by weaning and Escherichia coli

Diagnosis of Clostridium difficile infection using an UPLC-MS based metabolomics method.

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The fecal metabolome of Clostridium difficile (CD) infection is far from being understood, particularly its non-volatile organic compounds. The drawbacks of current tests used to diagnose CD infection hinder their application.The aims of this study were to

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