lysophosphatidylcholine/fatigue

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Metabonomics study of urine and plasma in depression and excess fatigue rats by ultra fast liquid chromatography coupled with ion trap-time of flight mass spectrometry.

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A novel metabonomic method based on fast liquid chromatography coupled with ion trap-time of flight mass spectrometry (UFLC/MS-IT-TOF) was applied to study the metabolic changes of plasma and urine in depression and excess fatigue rats. Principal component analysis (PCA) and partial least

Serum metabolite profiles of postoperative fatigue syndrome in rat following partial hepatectomy.

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Postoperative fatigue syndrome is a general complication after surgery. However, there is no ''gold standard'' for fatigue assessment due to the lack of objective biomarkers. In this study, a rodent model of postoperative fatigue syndrome based on partial hepatectomy was firstly established and

[Evaluation of the effect of the traditional Chinese medicine tongxinluo or ginseng on excess fatigue rats studied by metabonomics approach based on liquid chromatography-mass spectrometry].

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Excess fatigue is a pathological state of continuing accumulation of fatigue, which may cause the deterioration of body health, occurrence of diseases, and even lead to death. A metabonomics study was performed on the excess fatigue rats treated with traditional Chinese medicine Tongxinluo or

Analysis of the association between fatigue and the plasma lipidomic profile of inflammatory bowel disease patients

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Inflammatory bowel disease (IBD) is a chronic, relapsing non-infectious inflammatory condition of the intestinal tract with two main phenotypes -ulcerative colitis (UC) and Crohn's disease (CD)- and a globally increasing incidence and prevalence. Nearly 80% of the IBD patients with active disease

Phase I trial of ilmofosine as a 24 hour infusion weekly.

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Ilmofosine, an ether lipid derivative of lysophosphatidylcholine has antineoplastic activity in vitro and in vivo. Maximum efficacy in preclinical models is associated with prolonged exposure to the drug. In a Phase I trial of a weekly 2 hour infusion schedule of ilmofosine, a syndrome of lethargy,

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