menadione/rapeseed

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Prevention by menadione of the hepatotoxic effects in chickens fed rapeseed meal. Observations on coagulation factors and cytochrome P-450.

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Rapeseed meal, the residue after oil extraction, is an animal feed of great commercial interest. Some genetic strains of rapeseed yield a meal which when fed in high concentration produces hemorrhagic lesions in the liver of chickens. These lesions are reduced in incidence by the simultaneous

Rapeseed oil-rich diet alters in vitro menadione and nimesulide hepatic mitochondrial toxicity.

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Diet-induced changes in the lipid composition of mitochondrial membranes have been shown to influence physiological processes. However, the modulation effect of diet on mitochondrially-active drugs has not yet received the deserved attention. Our hypothesis is that modulation of membrane dynamics by

Experimental systems which modify and simulate rapeseed-induced liver haemorrhages in in-lay hens.

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The occurrence of liver haemorrhages was compared when diets containing 30 or 40 per cent rapeseed meal (RSM) or 30 per cent soybean meal (SBM), with and without experimental additives, were fed to in-lay hens of a commercial egg-producing strain for 12 weeks. The incidence of haemorrhages was

Influence of added menadione (vitamin K3) on dissolution and dimerization of tocopherols and autoxidation of triacylglycerols during storage of plant oils.

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The effect of added menadione (vit. K3) to stored rapeseed and soybean oil on the dissolution and dimerization of natural tocopherols and autoxidation of triacylglycerols was studied. Commercial rapeseed and soybean oils with added menadione and pure oil were stored at +20 degrees C in brown and

Dietary intake of menaquinone-4 may determine hepatic and pancreatic menaquinone-4 in chickens.

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OBJECTIVE The aim of this study was to determine the biological effects of natural dietary intake of vitamin K as phylloquinone (K(1)) and menaquinone-4 (MK-4) and a control diet also containing menadione (K(3)) on levels of K(1) and total MK-4 (menaquinone-4) and menaquinone-4-2,3-epoxide (MK-4O))

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