myopia/hypoxia

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Scleral hypoxia is a target for myopia control.

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Worldwide, myopia is the leading cause of visual impairment. It results from inappropriate extension of the ocular axis and concomitant declines in scleral strength and thickness caused by extracellular matrix (ECM) remodeling. However, the identities of the initiators and signaling pathways that

Changes in myopia with low-Dk hydrogel and high-Dk silicone hydrogel extended wear.

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OBJECTIVE This study compared changes in myopia between wearers of high-oxygen permeability (Dk) silicone hydrogel lenses and low-Dk hydrogel lenses after 1 year of extended wear (EW). METHODS Ninety-two adult subjects were randomly assigned to a lens type. Subjective refraction and autokeratometry

Clinical signs of hypoxia with high-Dk soft lens extended wear: is the cornea convinced?

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OBJECTIVE To assess the effectiveness of high-Dk soft contact lenses with oxygen transmissibility (Dk/L) beyond the critical level required to avoid corneal edema during overnight wear. METHODS The most up-to-date data available on clinical signs of hypoxia with high-Dk contact lenses is

Regulation of pigment epithelium-derived factor production and release by retinal glial (Müller) cells under hypoxia.

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OBJECTIVE To assess the regulation of pigment epithelium-derived factor (PEDF) production by retinal Müller glial cells, especially under ischemic or hypoxic conditions. METHODS PEDF was determined in surgically excised retinal tissue originating from patients with ischemic diabetic retinopathy and

[Childhood retinal detachment: ROP and myopia].

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This article reviews the cause and treatment options for retinopathy of prematurity (ROP)-related tractional detachment and detachments in ROP residuals during childhood and early adulthood. Retinal vascularisation is incomplete after premature birth. Phase I of ROP consists of a delayed retinal

[Biochemical parameters and prediction of the development of glaucoma in patients with progressive myopia].

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Examinations were made in 3 groups of patients aged 15 to 27 years: 1) patients with rapidly progressive high-grade myopia; 2) those with slowly progressive high-grade myopia; 3) healthy individuals (controls). Groups 1 and 2 patients had elevated levels of lactic and pyruvic acids along with the

Topical bendazol inhibits experimental myopia progression and decreases the ocular accumulation of HIF-1α protein in young rabbits

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Purpose: To investigate the inhibitory effect of bendazol on form-deprivation myopia (FDM) in rabbits as well as the underlying biochemical processes. Methods: Forty-eight

Crosstalk between EP2 and PPARα Modulates Hypoxic Signaling and Myopia Development in Guinea Pigs

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Purpose: Cyclic adenosine monophosphate (cAMP) and peroxisome proliferator-activated receptor alpha (PPARα) levels mediate extracellular matrix (ECM) changes by altering the levels of hypoxia-inducible factor 1-alpha (HIF-1α) in various

Anti-Aging Approach for Ocular Disorders: from Dry Eye to Retinitis Pigmentosa and Myopia.

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More than 90% of ocular diseases, such as glaucoma, age-related macular degeneration, and dry eye, are age-related with the incidence increasing with age. Furthermore, although retinitis pigmentosa and myopia may be associated with hereditary factors, they are also considered age-related diseases

[The specific features of delivery in women with gestosis and myopia].

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The treatment option for retinal degeneration, including peripheral vitreochorioretinal degenerations, was performed in 415 pregnant females (including 25 healthy pregnant females); it differed in patients with myopia and gestosis at labor and in the postpartum period in the fact that regularity was

Oxidative stress in myopia.

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Myopia affected approximately 1.6 billion people worldwide in 2000, and it is expected to increase to 2.5 billion by 2020. Although optical problems can be corrected by optics or surgical procedures, normal myopia and high myopia are still an unsolved medical problem. They frequently predispose

Scleral HIF-1α is a prominent regulatory candidate for genetic and environmental interactions in human myopia pathogenesis

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Background: Myopia is a good model for understanding the interaction between genetics and environmental stimuli. Here we dissect the biological processes affecting myopia progression. Methods:

Hot Topics in Retinopathy of Prematurity.
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Retinopathy of prematurity (ROP) is a condition seen in premature infants that is characterized by abnormal retinal blood vessel growth incited by relative hyperoxia and followed by hypoxia. It can have severe consequences ranging from high myopia to blindness. This article reviews recent "hot"

The future of silicone hydrogels.
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Significant advances during the past decade in silicone hydrogel lenses have made them the primary mode for new contact lens wear. Their dominance in the market place is driven largely by the elimination of structural and physiological changes induced by contact lens-induced hypoxia, as exemplified

[Changes in myopic refractive errors after 9 months of extensive wear of hydrogel lenses with high oxygen permeability and compared with those with low permeability].
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BACKGROUND A small but significant increase in myopia after extended wear of low oxygen permeability (Dk) hydrogel lenses has been previously reported; however, the specific impact of hypoxia on refractive status and corneal curvature with extended wear are not well documented. THE PURPOSE of this

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