RNA repeat expansions are responsible for more than 30 incurable diseases. Among them is myotonic dystrophy type 1 (DM1), the most common form of adult on-set muscular dystrophy. DM1 is caused by an r(CUG) repeat expansion [r(CUG)p>expp>] located in the 3' untranslated region (UTR) of the
Myotonic dystrophy type-1 (DM1) is the most prevalent form of muscular dystrophy in adults. This disorder is an RNA-dominant disease, caused by expansion of a CTG repeat in the DMPK gene that leads to a misregulation in the alternative splicing of pre-mRNAs. The longer muscleblind-like-1 (MBNL1)
Myogenic cell clones were grown in triplicates from 3 patients with Duchenne muscular dystrophy, 5 with late onset myotonic dystrophy, 2 with spinal muscular atrophy, 6 male children controls, 4 adult controls and 6 normal aborted fetuses (10-12 weeks old). The clones from patients with myotonic
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