Pyrene-imprinted microbeads that display molecular recognition towards polyaromatic hydrocarbons (PAHs) were obtained by the aqueous suspension thermopolymerization of a mixture of template, 4-vinylpyridine and divinylbenzene in the molar ratio of 1:8:40. The microbeads were packed into an HPLC
The objective of this study was to develop an approach for incorporating tissue composition data into physiologically based pharmacokinetic (PBPK) models in order to facilitate "built-in" calculation of tissue: air partition coefficients (PCs) of volatile organic chemicals. The approach involved
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