narcolepsy/vomiting

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Postoperative outcome of patients with narcolepsy. A retrospective analysis.

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OBJECTIVE To determine the postoperative outcome of narcolepsy patients, a population that may be at increased risk of perioperative complications, including postoperative hypersomnia, prolonged emergence after general anesthesia, and apnea. METHODS Retrospective chart review. METHODS Academic

Pharmacokinetics of pitolisant in children and adolescents with narcolepsy.

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OBJECTIVE

To evaluate the pharmacokinetic profile and tolerability of pitolisant, a selective histamine 3 (H₃)-receptor antagonist/inverse agonist, in children and adolescents with narcolepsy.

METHODS

This multicenter, open-label, single-dose

Dosing regimen effects of modafinil for improving daytime wakefulness in patients with narcolepsy.

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In a multicenter, randomized, double-blind study the authors compared the efficacy of modafinil 400 mg once daily, 400 mg given in a split dose, or 200 mg once daily for maintaining wakefulness throughout the day in patients (N = 32) with narcolepsy reporting a positive daytime response to modafinil

Sodium oxybate for narcolepsy with cataplexy: systematic review and meta-analysis.

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OBJECTIVE To assess the efficacy and safety of sodium oxybate (SXB) in narcolepsy-cataplexy patients. METHODS Systematic review and meta-analysis. METHODS Adults with narcolepsy-cataplexy. METHODS SXB. RESULTS Electronic databases (e.g., MEDLINE) and references of included studies were searched to

Treatment of paediatric narcolepsy with sodium oxybate: a double-blind, placebo-controlled, randomised-withdrawal multicentre study and open-label investigation.

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BACKGROUND Narcolepsy is a lifelong neurological disorder with onset commonly in childhood or adolescence. No drugs are indicated for cataplexy and excessive daytime sleepiness in paediatric patients with narcolepsy. Sodium oxybate is approved for use in adult patients with excessive daytime

Atypical presentations of neuromyelitis optica.

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Neuromyelitis optica (NMO) is an inflammatory disease of central nervous system classically characterized by acute, severe episodes of optic neuritis and longitudinally extensive transverse myelitis, usually with a relapsing course. The identification of an autoantibody exclusively detected in NMO

Postoperative analgesic effect of different doses of naloxone combined with butorphanol and psychological nursing intervention.

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Cesarean section, as a stressor, inevitably produces negative emotions such as anxiety and may cause intraoperative discomfort and postoperative pain. Butorphanol is a commonly used analgesic in cesarean section. Butorphanol's postoperative analgesia can reduce the incidence of postoperative

On the advisability of surgical treatment of children with kinking of the internal carotid artery.

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The aim of the present work was to evaluate the long-term results of surgical treatment of children with pathological kinking of the internal carotid artery (PK ICA). Fifty children (42 boys and 8 girls) aged 5 to 16 years (range 11.1+/-0.32) with PK ICA were operated on. PK ICA was diagnosed by

[Treatment of atypical absences with a combination of succinimide and dipropylacetate (author's transl)].

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Fifteen epileptic patients with mild seizures of the narcolepsy type were treated with a combination of succinimide (average dose 750 mg) and dipropylacetate (average dose 1,200 mg), medication with each drug alone having brought no success. The combination of drugs stopped the seizures in eleven

Hyponatraemia and cerebral oedema due to a modafinil overdose

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Modafinil is a non-amphetamine stimulant that is prescribed for narcolepsy-associated sleepiness as well as reported off-licence uses among university students looking to improve wakefulness and focus. There is limited information in the medical literature about supratherapeutic modafinil dosage,

Gamma-hydroxybutyric acid: an emerging recreational drug.

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Gamma-hydroxybutyric acid (GHB) is no longer used as an anaesthetic induction agent because of the high incidence of myoclonic seizures and vomiting. However, it is used occasionally in Europe for the treatment of narcolepsy, alcohol dependence and opiate dependence. Since the early 1990s, GHB has

GHB pharmacology and toxicology: acute intoxication, concentrations in blood and urine in forensic cases and treatment of the withdrawal syndrome.

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The illicit recreational drug of abuse, γ-hydroxybutyrate (GHB) is a potent central nervous system depressant and is often encountered during forensic investigations of living and deceased persons. The sodium salt of GHB is registered as a therapeutic agent (Xyrem®), approved in some countries for

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