necrobiotic xanthogranuloma/edema

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[Necrobiotic xanthogranuloma. Differential diagnosis, treatment and systemic involvement. Case report].

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METHODS A 48-year-old male was referred to our hospital for further evaluation of eyelid edema with bilateral yellowish ulcerated nodules. Suspecting a xanthogranulomatosis, imaging tests and biopsy were performed with diagnosis of necrobiotic xanthogranuloma. IgG monoclonal gammapathy was diagnosed

Necrobiotic xanthogranuloma without a monoclonal gammopathy.

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Necrobiotic xanthogranuloma (NXG) is an indolent non-Langerhans cell histiocytosis characterized by yellow xanthomatous plaques that tend to ulcerate. Necrobiotic xanthogranulomas have a predilection for the bilateral periorbital region and often present with consequential ophthalmic findings.

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