nephrocalcinosis/phosphatase

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Characterising Pain, QoL, Body Composition, Arterial Stiffness, Muscles and Bones in Adult Persons With XLH and Healthy Controls

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Hereditary hypophosphatemia (XLH) is a rare, inherited disease. Loss-of-function mutation in PHEX results in excess fibroblast growth factor 23 (FGF23) production and manifests as rickets in children and osteomalacia in adults. FGF23 is a hormone that reduces renal phosphate reabsorption, decreases

Effects of PTH Replacement on Bone in Hypoparathyroidism

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Objectives The primary objective of this study is to evaluate the skeletal effects of hormone replacement therapy with HPTH in hypoparathyroidism. Study Population This study will enroll up to 69 subjects with physician-diagnosed hypoparathyroidism. Design This study will treat hypoparathyroid

Vitamin D Dose-Response Study to Establish Dietary Requirements in Infants

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Vitamin D status is currently judged by serum 25(OH)D and the parathyroid hormone (PTH)-25(OH)D dynamic (1). The ultimate effect of vitamin D on human health is a healthy skeleton, which is characterized in infancy by normal linear growth and bone mineral accretion and absence of bone related

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