nephrogenic fibrosing dermopathy/nausea

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Good MRI images: to Gad or not to Gad?

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Gadolinium-based magnetic resonance imaging (MRI) contrast agents (Gad-CA) were formerly considered as alternatives to X-ray-employed iodinated media. Although originally thought to be nonnephrotoxic and proven to be nonhazardous in a healthy population, the Gad-CA safety issue is progressively more

Feasibility and safety of perfusion MRI for Legg-Calvé-Perthes disease.

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BACKGROUND Recent studies have suggested that perfusion magnetic resonance imaging (pMRI) using gadolinium contrast and a subtraction technique can provide useful prognostic information in Legg-Calvé-Perthes disease (LCPD) and allow earlier stratification for outcome. There are, however, sparse data

Safety of Gadobutrol: Results From 42 Clinical Phase II to IV Studies and Postmarketing Surveillance After 29 Million Applications.

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The aim of this study was to provide a systematic safety analysis of gadobutrol after more than 29 million applications in clinical routine. Forty-two clinical development phase II to IV studies on gadobutrol or comparator and the postmarketing safety surveillance database for gadobutrol (1998-2015)

Gadolinium in pediatric cardiovascular magnetic resonance: what we know and how we practice.

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BACKGROUND The association of gadolinium-based contrast agents (GBCAs) with nephrogenic systemic fibrosis (NSF) has led to a heightened awareness towards patients' renal function. Whereas detailed guidelines exist for the use of GBCAs in adult patients, best practice is less well defined in

Safety of gadobutrol, a new generation of contrast agents: experience from clinical trials and postmarketing surveillance.

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OBJECTIVE To assess the clinical safety and tolerability of the macrocyclic contrast agent gadobutrol (Gadovist/Gadavist) overall and in specific patient populations based on clinical trials and postmarketing experience. METHODS In total, 5545 patients enrolled in 34 prospective clinical studies

Acute phase reaction to gadolinium-DTPA in dialysis patients.

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BACKGROUND Several late sequelae of the administration of gadolinium (Gd)-containing MRI contrast agents have been described in patients with advanced renal failure. In an observational series, we found a remarkable frequency of peracute reactions after administration of Gd-DTPA used for

Observational study on the safety profile of gadoterate meglumine in 35,499 patients: The SECURE study.

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To investigate the safety of gadoterate meglumine and identify the incidence of nephrogenic systemic fibrosis (NSF). An international prospective observational study was conducted from November 2008 to June 2013. A total of 35,499 adults and children who were scheduled to undergo contrast-enhanced

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