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nevus of ota/melasma
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Topical mitomycin chemotherapy for conjunctival malignant melanoma and primary acquired melanosis with atypia: 12 years' experience.
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OBJECTIVE
To report 12-year follow-up experience with topical mitomycin chemotherapy for diffuse and multifocal primary acquired melanosis (PAM) with atypia and conjunctival melanoma.
METHODS
Interventional case series of 16 patients. Mitomycin was a primary treatment for residual epithelial disease
The treatment of primary acquired melanosis (PAM) with atypia by topical Mitomycin C.
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OBJECTIVE
To report our results of 12 consecutive patients with conjunctival primary acquired melanosis (PAM) with atypia who were treated by topical Mitomycin C (MMC).
METHODS
Retrospective interventional consecutive case series.
METHODS
Twelve patients with PAM with atypia in one of their eyes who
Limbal stem cell deficiency after topical mitomycin C therapy for primary acquired melanosis with atypia.
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OBJECTIVE
To describe the incidence, characteristics, risk factors, and clinical outcome of limbal stem cell deficiency (LSCD) resulting from topical treatment with mitomycin C (MMC) for primary acquired melanosis (PAM) with atypia.
METHODS
Retrospective, observational case series.
METHODS
Patients
Primary acquired melanosis of the conjunctiva: experience with 311 eyes.
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OBJECTIVE
To evaluate clinical features and risks for transformation of conjunctival primary acquired melanosis (PAM) into melanoma.
METHODS
Retrospective chart review and Kaplan-Meier estimates of times to PAM enlargement, recurrence, and transformation into melanoma.
METHODS
PAM enlargement,
Primary acquired melanosis of the conjunctiva: risks for progression to melanoma in 311 eyes. The 2006 Lorenz E. Zimmerman lecture.
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OBJECTIVE
To evaluate the clinical features and risks for transformation of conjunctival primary acquired melanosis (PAM) into melanoma.
METHODS
Noncomparative case series.
METHODS
Three hundred eleven eyes with conjunctival PAM without melanoma at initial examination from a single-center tertiary
Induction of melasma by 1064-nm Q-switched neodymium:yttrium-aluminum-garnet laser therapy for acquired bilateral nevus of Ota-like macules (Hori nevus): A study on related factors in the Chinese population.
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Laser treatment has emerged as a common treatment modality for acquired bilateral nevus of Ota-like macules (ABNOM). To identify the ratio of melasma induction and exacerbation before and after laser therapy for ABNOM and to observe the risk factors related to the induction and exacerbation of
Nevus of Ota associated with meningeal melanosis and intracranial melanoma. Case report.
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A case is reported of a patient in whom an intracranial extracerebral melanoma developed in association with a life-long nevus of Ota. Melanotic pigmentation of the skull, periosteum, and meninges beneath the nevus was found at operation.
Q-switched ruby laser treatment of oculodermal melanosis (nevus of Ota).
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The Q-switched ruby laser at 694 nm, a wavelength well absorbed by melanin relative to other optically absorbing structures in skin, causes highly selective destruction of pigment-laden cells. In addition, the 20- to 40-ns pulse duration produced by this laser approximates the thermal relaxation
Cell growth and p53 expression in primary acquired melanosis and conjunctival melanoma.
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OBJECTIVE
To evaluate cell growth and the pattern of p53 suppressor gene expression in atypical primary acquired melanosis (PAM) and in recurrent conjunctival melanoma.
METHODS
Eighteen specimens of PAM with atypia and 24 specimens, comprising early and late lesions, from 12 patients with
Sinonasal melanoma arising from conjunctival primary acquired melanosis.
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A 66-year-old woman was treated with excision and cryotherapy for recurrent primary acquired melanosis (PAM) with atypia of the right conjunctiva. Four years later, she developed a melanoma of the ipsilateral inferior turbinate and nasolacrimal duct. She was treated with right medial maxillectomy
Conjunctival Primary Acquired Melanosis: Is It Time for a New Terminology?
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OBJECTIVE
To review the diagnostic categories of a group of conditions referred to as "primary acquired melanosis."
METHODS
Literature review on the subject and proposal of an alternative diagnostic schema with histopathologic and immunohistochemical illustrations.
METHODS
Standard
Conjunctival amelanotic malignant melanoma arising in primary acquired melanosis sine pigmento.
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BACKGROUND
The authors describe an amelanotic malignant melanoma of the conjunctiva in association with primary acquired melanosis (PAM) sine pigmento, and highlight the clinical and pathologic features of this rare entity.
METHODS
Histopathologic and immunohistochemical studies were performed on a
Primary acquired melanosis of the conjunctiva is melanoma in situ.
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This essay places the concept of "primary acquired melanosis" of the conjunctiva in historical perspective and shows that it and its analogs, namely, lentigo-melanosis (Hutchinson), melanotic freckle (Hutchinson), melanose circonscrite precancereuse (Dubrueilh), melanotische precancerose (Miescher),
Animal model of conjunctival primary acquired melanosis.
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A condition clinically identical to human conjunctival primary acquired melanosis (PAM) was induced in 16 of 20 Dutch (pigmented) rabbits after weekly topical 60-microliters applications of a 1% solution of 7,12-dimethylbenz[a]anthracene (DMBA) in acetone. Pigment stippling appeared in the
Topical mitomycin treatment for primary acquired melanosis of the conjunctiva.
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A case of primary acquired melanosis of the conjunctiva primarily treated with topical mitomycin chemotherapy is presented. The patient underwent treatment with one 2-week course of topical mitomycin 0.02% four times daily, followed 4 weeks later by a 2-week course of topical mitomycin 0.04% four
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