ocotea foetens/hypersensitivity

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Protective effects of Yangambin - a naturally occurring platelet-activating factor (PAF) receptor antagonist - on anaphylactic shock in rats.

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The purpose of this study was to investigate the ability of yangambin to inhibit cardiovascular collapse and to reduce the mortality due to systemic anaphylaxis induced by antigen challenge in actively sensitized rats. The i.v. injection of the antigen (ovalbumin, 250 or 500 μg/kg), induced a

Evaluation of the mutagenic potential of yangambin and of the hydroalcoholic extract of Ocotea duckei by the Ames test.

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Ocotea duckei Vattimo is a plant popularly known as "louro-de-cheiro" found in the northeast of Brazil. Traditional medicinal uses of this plant are not known, but recent pharmacological studies with the isolated major constituent yangambin have shown various qualities: platelet activating factor

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