oncogene addiction/staurosporine

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Protein kinase CK2 accumulation in "oncophilic" cells: causes and effects.

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At variance with protein kinases expressed by oncogenes, CK2 is endowed with constitutive activity under normal conditions, and no CK2 gain-of-function mutants are known. Its amount, however, is abnormally high in malignant cells where it appears to be implicated in many of the cell biology

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