osteophyte/hypoxia

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Role of hypoxia-inducible factor 1 alpha in the integrity of articular cartilage in murine knee joints.

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BACKGROUND Chondrocytes have to withstand considerable hypoxic conditions within the avascular articular cartilage. The present study investigated the effects of inhibiting or stabilizing hypoxia-inducible factor (HIF)-1 alpha by 2-methoxyestradiol or dimethyloxaloylglycine on the progression of

Case of critical complication after surgery for ankylosing spinal hyperostosis.

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We experienced a case who received a bone resection for ankylosing spinal hyperostosis through the anterior approach. He subsequently became asphyxic and suffered a cardiopulmonary arrest owing to a postoperative hematoma. His complaint before the surgery was sticking of his throat and dyspnea that

Development process of traumatic heterotopic ossification of the temporomandibular joint in mice.

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The exact development process underlying traumatic heterotopic ossification of the temporomandibular joint (THO-TMJ) is largely unclear. In this study, we try to explore the histological development process of THO-TMJ.Condylar cartilage of one-month-old

FGF2 High Molecular Weight Isoforms Contribute to Osteoarthropathy in Male Mice.

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Humans with X-linked hypophosphatemia (XLH) and Hyp mice, the murine homolog of the disease, develop severe osteoarthropathy and the precise factors that contribute to this joint degeneration remain largely unknown. Fibroblast growth factor 2 (FGF2) is a key regulatory growth factor in

[Destructive arthrosis of the hip. Natural history, pathogenesis, and radiographic features].

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Degenerative hip arthritis is caused by the joint failing to bear the normal walk load, because of changes in the anatomical components and of some factors leading to static or dynamic unbalance of the joint surfaces. Degenerative arthritis usually evolves slowly, but its evolution is rapid under

[Mechanism of molecular backgrounds of osteoarthritis].

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In efforts to know the molecular backgrounds underlying the osteoarthritis (OA) development, examinations using the experimental mouse models confirmed that type X collagen (COL10A1) that is characteristic of chondrocyte hypertrophy and initiates endochondral ossification was strongly expressed in

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