osthol/cnidium

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Osthol ameliorates fat milk-induced fatty liver in mice by regulation of hepatic sterol regulatory element-binding protein-1c/2-mediated target gene expression.

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The objective of this study was to examine the therapeutic effect of osthol, an active constituent of Cnidium monnieri (L.) Cusson (Apiaceae), in hyperlipidemic fatty liver mice and investigate the potential mechanism of the osthol treatment. A mouse model with hyperlipidemic fatty liver was induced

Osthol regulates hepatic PPAR alpha-mediated lipogenic gene expression in alcoholic fatty liver murine.

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Our previous studies found that osthol, an active constituent isolated from Cnidium monnieri (L.) Cusson (Apiaceae), could ameliorate the accumulation of lipids and decrease the lipid levels in serum and hepatic tissue in alcohol-induced fatty liver mice and rats. The objective of this study was to

[Determination of osthol and imperatorin in Cnidium monnieri (L.) cuss by fluorometry TLC scanning].

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The main active constituents--osthol and imperatorin were isolated from Cnidium monnieri (L.) Cuss and then used as standards for their determination in the crude drug by fluorometry TLCS. The fructus Cnidii was macerated with ethanol overnight and the ethanolic extract was spotted on a silica gel

Optimization of extraction conditions for osthol, a melanogenesis inhibitor from Cnidium monnieri fruits.

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BACKGROUND Coumarin derivatives have been reported to inhibit melanin biosynthesis. OBJECTIVE The melanogenesis inhibitory activity of osthol, a major coumarin of the fruits of Cnidium monnieri Cusson (Umbelliferae), and optimized extraction conditions for the maximum yield from the isolation of

Preparative isolation of osthol and xanthotoxol from Common Cnidium Fruit (Chinese traditional herb) using stepwise elution by high-speed counter-current chromatography.

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Preparative high-speed counter-current chromatography (HSCCC) was successfully used for isolation and purification of osthol and xanthotoxol from Cnidium monnieri (L.) Cusson (Common Cnidium Fruit) using stepwise elution with a pair of two-phase solvent systems composed of n-hexane-ethyl

[Effects of osthol and total-coumarins from Cnidium monnieri on immunological function in kidney yang deficiency mice].

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Mice were injected intraperitoneally with hydrocortisone acetate to replicate the animal model of Kidney Yang Deficiency (KYD). Osthol and total-coumarins (TCR) from the fruit of Cnidium monnieri were administered orally to model mice. The effects of osthol and TCR on the immunological function of

Effects of Osthol Isolated from Cnidium monnieri Fruit on Urate Transporter 1.

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(1) Background: Crude drugs used in traditional Japanese Kampo medicine or folk medicine are major sources of new chemical entities for drug discovery. We screened the inhibitory potential of these crude drugs against urate transporter 1 (URAT1) to discover new drugs for hyperuricemia. (2) Methods:

Effects of osthol on blood pressure and lipid metabolism in stroke-prone spontaneously hypertensive rats.

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Osthol, a coumarin compound, was isolated from the dried fruits of Cnidium monnieri (Umbelliferae) and the effect of dietary osthol on hypertension and lipid metabolism was examined in stroke-prone spontaneously hypertensive rats (SHRSP). Six-week-old male SHRSP were fed the experimental diet

Effect of the Chinese herb extract osthol on IL-4-induced eotaxin expression in BEAS-2B cells.

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BACKGROUND Asthma is an allergic inflammatory disease of the airways. The interaction between bronchial epithelial cells and eosinophils is an important feature of an asthma attack. Eotaxin, an eosinophil-specific C-C chemokine, is a potent chemoattractant involved in the mobilization of eosinophils

Anti-allergic effects of cnidii monnieri fructus (dried fruits of Cnidium monnieri) and its major component, osthol.

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Anti-allergic effects (types I and IV) of the 70% ethanol extract (CM-ext) obtained from Cnidii Monnieri Fructus (dried fruits of Cnidium monnieri) were investigated on 48 h homologous passive cutaneous anaphylaxis (PCA), 2, 4-dinitrofluorobenzene (DNFB)-induced contact dermatitis and picryl

Antitumor effects of Osthol from Cnidium monnieri: an in vitro and in vivo study.

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Cnidium monnieri (L.) Cusson is a Chinese medicine which is used widely by traditional medicine doctors. Osthol is a major bio-activity compound of the herb. In this study, osthol was isolated from C. monnieri and its in vitro and in vivo antitumor effects studied. The results of the in vitro study

Reduction of rat cardiac hypertrophy by osthol is related to regulation of cardiac oxidative stress and lipid metabolism.

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The objective of this study was to examine the therapeutic effect of osthol, a coumarin compound isolated from the fruit of Cnidium monnieri (L.) Cusson, on cardiac hypertrophy in rats and investigate its potential mechanisms. The rats with cardiac hypertrophy induced by renovascular hypertension

Osthol, a coumarin isolated from common cnidium fruit, enhances the differentiation and maturation of osteoblasts in vitro.

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The effect of osthol on osteoblasts was investigated in primary osteoblastic cells isolated from newborn Wistar rats. Osthol was supplemented into cultured medium at 10⁻⁷, 10⁻⁶, 10⁻⁵ and 10⁻⁴ mol/l, respectively. No stimulating effect was found on cell proliferation, but 10⁻⁵ mol/l osthol caused a

[The anti-allergic activity of osthol extracted from the fruits of Cnidium monnieri (L.) Cusson].

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[Effects of coumarins from cnidium monnieri on the function of pituitary-adrenocortical axis in kidney yang deficiency rats].

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OBJECTIVE To observe the effect of Cnidium monnieri in Kidney Yang Deficiency rats. METHODS Rats were injected intraperitoneally with hydrocortisone acetate to replicate the animal model of Kidney Yang Deficiency. Osthol, total-coumarins (TCR) from the fruit of Cnidium monnieri and positive control

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