osthol/leukemia

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Cytotoxic activity of coumarins from the fruits of Cnidium monnieri on leukemia cell lines.

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Cnidii monnieri Fructus [CmF; Cnidium monnieri (L.) Cusson] is used as a tonic agent in traditional Chinese medicine. In a previous Chinese herb-cytotoxicity screening test, the ethanol extract of CmF exhibited strong effects on human leukemia (HL-60), cervical carcinoma (HeLa) and colorectal

Synthesis and biological evaluation of novel osthol derivatives as potent cytotoxic agents.

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Natural product, osthol has been found to have important biological and pharmacological roles. The unmet needs in cancer therapeutics makes its derivatization an important and exciting field of research. Keeping this in view, a whole new series of diverse analogues of osthol (1) were prepared

Potential Anticancer Properties of Osthol: A Comprehensive Mechanistic Review.

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Cancer is caused by uncontrolled cell proliferation which has the potential to occur in different tissues and spread into surrounding and distant tissues. Despite the current advances in the field of anticancer agents, rapidly developing resistance against different chemotherapeutic drugs and

Antiproliferative effects of isopentenylated coumarins isolated from Phellolophium madagascariense Baker.

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From the leaves of Phellolophium madagascariense Baker (Apiaceae), an endemic herb to Madagascar, three known coumarins (osthol, murraol and meranzin hydrate) have been isolated and identified. This is the first report of these compounds in this species. The structural elucidations were based on the

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